Grainyhead‐like‐2 confers NK‐sensitivity through interactions with epigenetic modifiers
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.11.006
Abstract: HighlightsGRHL2 is a master programmer of the epithelial phenotype that sensitized cells to NK killing at the level of NK‐target cell synaptogenesis.Sensitization was mediated by the up‐regulation of ICAM‐1.GRHL2‐KMT2C/D interactions and p300 inhibition were important… read more here.
Keywords: epithelial phenotype; grainyhead like; expression; target cell ... See more keywords
Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.12.016
Abstract: Epithelial cell polarity, adhesion, proliferation, differentiation and survival are essential for morphogenesis of various organs and tissues including the ocular lens. The molecular mechanisms regulating the lens epithelial phenotype however, are not well understood. Here… read more here.
Keywords: mouse lens; ankg; morphogenesis; cell ... See more keywords
Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-5204-x
Abstract: BackgroundPancreatic cancer (PC) is a highly aggressive disease, and the lethality of this disease stems from early metastatic dissemination where surgical removal cannot provide a cure. Improvement of the therapeutic outcome and overall survival of… read more here.
Keywords: sema5a knockdown; maintains epithelial; expression; cancer ... See more keywords
MicroRNA-9 enhances sensitivity to cetuximab in epithelial phenotype hepatocellular carcinoma cells through regulation of the eukaryotic translation initiation factor 5A-2
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2017.7399
Abstract: Hepatocellular carcinoma (HCC) is one of the most widespread malignant human tumors worldwide. Treatment options include radiotherapy, surgical intervention and chemotherapy; however, drug resistance is an ongoing treatment concern. In the present study, the effects… read more here.
Keywords: phenotype; hcc; sensitivity; expression ... See more keywords