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   Articles with "epithelial plasticity" as a keyword



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Bittersweet tumor development and progression: Emerging roles of epithelial plasticity glycosylations

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recommendations! Published in 2019 at "Advances in Cancer Research"

DOI: 10.1016/bs.acr.2019.01.002

Abstract: &NA; Altered metabolism is one of the hallmarks of cancer. The best‐known cancer metabolic anomaly is an increase in aerobic glycolysis, which generates ATP and other basic building blocks, such as nucleotides, lipids, and proteins… read more here.

Keywords: glcnacylation; cancer; development; epithelial plasticity ... See more keywords
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Abstract 1033: Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer

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recommendations! Published in 2019 at "Tumor Biology"

DOI: 10.1158/1538-7445.am2019-1033

Abstract: Pancreatic ductal adenocarcinoma (PDA) is characterized by an activating mutation in KRAS. Direct inhibition of KRAS through pharmacological means remains a challenge; however, targeting key KRAS effectors has therapeutic potential. We investigated the contribution of… read more here.

Keywords: axl; tbk1; axl mediated; cancer ... See more keywords
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Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer.

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recommendations! Published in 2019 at "JCI insight"

DOI: 10.1172/jci.insight.126117

Abstract: Pancreatic ductal adenocarcinoma (PDA) is characterized by an activating mutation in KRAS. Direct inhibition of KRAS through pharmacological means remains a challenge; however, targeting key KRAS effectors has therapeutic potential. We investigated the contribution of… read more here.

Keywords: epithelial plasticity; axl; tbk1; mediated activation ... See more keywords
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Epithelial plasticity in COPD results in cellular unjamming due to an increase in polymerized actin

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recommendations! Published in 2022 at "Journal of Cell Science"

DOI: 10.1242/jcs.258513

Abstract: ABSTRACT The airway epithelium is subjected to insults such as cigarette smoke (CS), a primary cause of chronic obstructive pulmonary disease (COPD) and serves as an excellent model to study cell plasticity. Here, we show… read more here.

Keywords: plasticity copd; epithelial plasticity; polymerized actin; cellular unjamming ... See more keywords
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Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers

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recommendations! Published in 2019 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2019.01049

Abstract: Cellular plasticity, a feature associated with epithelial-to-mesenchymal transition (EMT), contributes to tumor cell survival, migration, invasion, and therapy resistance. Phenotypic plasticity of the epithelium is a critical feature in multiple phases of human cancer in… read more here.

Keywords: behind wheel; driven cancers; cellular plasticity; kras driven ... See more keywords