How SARS-CoV-2 might affect potassium balance via impairing epithelial sodium channels?
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology Reports"
DOI: 10.1007/s11033-021-06642-0
Abstract: Severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) is the causative agent of current coronavirus disease 2019 (COVID-19) pandemic. Electrolyte disorders particularly potassium abnormalities have been repeatedly reported as common clinical manifestations of COVID-19. Here, we… read more here.
Keywords: potassium; affect potassium; potassium balance; epithelial sodium ... See more keywords
The synaptic action of Degenerin/Epithelial sodium channels
Sign Up to like & getrecommendations! Published in 2018 at "Channels"
DOI: 10.1080/19336950.2018.1495006
Abstract: ABSTRACT Degenerin/Epithelial Sodium Channels (DEG/ENaCs) are a large family of animal-specific non-voltage gated ion channels, with enriched expression in neuronal and epithelial tissues. While neuronal DEG/ENaCs were originally characterized as sensory receptor channels, recent studies… read more here.
Keywords: degenerin epithelial; deg enac; epithelial sodium; sodium channels ... See more keywords
Segregated expression of ENaC subunits in taste cells.
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DOI: 10.1093/chemse/bjaa004
Abstract: Salt taste is one of the 5 basic taste qualities. Depending on the concentration, table salt is perceived either as appetitive or aversive, suggesting the contribution of several mechanisms to salt taste, distinguishable by their… read more here.
Keywords: taste; salt; sodium channel; channel ... See more keywords
Epithelial sodium channel biogenesis and quality control in the early secretory pathway
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000438
Abstract: Purpose of review The epithelial sodium channel, ENaC, is responsible for Na+ reabsorption in several epithelia and is composed of homologous &agr;, &bgr;, and &ggr; subunits. Here, we will explore the differential regulation of ENaC… read more here.
Keywords: secretory pathway; sodium; channel; early secretory ... See more keywords
Lovastatin attenuates hypertension induced by renal tubule‐specific knockout of ATP‐binding cassette transporter A1, by inhibiting epithelial sodium channels
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14775
Abstract: We have shown that cholesterol is synthesized in the principal cells of renal cortical collecting ducts (CCD) and stimulates the epithelial sodium channels (ENaC). Here we have determined whether lovastatin, a cholesterol synthesis inhibitor, can… read more here.
Keywords: hypertension induced; atp binding; binding cassette; epithelial sodium ... See more keywords
Preclinical evaluation of the epithelial sodium channel inhibitor AZD5634 and implications on human translation
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Physiology - Lung Cellular and Molecular Physiology"
DOI: 10.1152/ajplung.00454.2021
Abstract: Airway dehydration causes mucus stasis and bacterial overgrowth in cystic fibrosis (CF), resulting in recurrent respiratory infections and exacerbations. Strategies to rehydrate airway mucus including inhibition of the epithelial sodium channel (ENaC) have the potential… read more here.
Keywords: physiology; epithelial sodium; inhibitor; sodium channel ... See more keywords
Epithelial Sodium Channel and Salt-Sensitive Hypertension.
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DOI: 10.1161/hypertensionaha.120.14481
Abstract: The development of high blood pressure is influenced by genetic and environmental factors, with high salt intake being a known environmental contributor. Humans display a spectrum of sodium-sensitivity, with some individuals displaying a significant blood… read more here.
Keywords: epithelial sodium; sodium; sensitive hypertension; salt sensitive ... See more keywords
The Epithelial Sodium Channel Is a Modifier of the Long‐Term Nonprogressive Phenotype Associated with F508del CFTR Mutations
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2017-0166oc
Abstract: &NA; Cystic fibrosis (CF) remains the most lethal genetic disease in the Caucasian population. However, there is great variability in clinical phenotypes and survival times, even among patients harboring the same genotype. We identified five… read more here.
Keywords: term nonprogressive; nonprogressive phenotype; long term; sodium channel ... See more keywords
Preclinical evaluation of the epithelial sodium channel inhibitor BI 1265162 for treatment of cystic fibrosis
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DOI: 10.1183/23120541.00429-2020
Abstract: Background Epithelial sodium channel (ENaC) is an important regulator of airway surface liquid volume; ENaC is hyperactivated in cystic fibrosis (CF). ENaC inhibition is a potential therapeutic target for CF. Here, we report in vitro… read more here.
Keywords: inhibitor; enac; transport; inhibition ... See more keywords
Liddle syndrome due to a novel mutation in the γ subunit of the epithelial sodium channel (ENaC) in family from Russia: a case report
Sign Up to like & getrecommendations! Published in 2019 at "BMC Nephrology"
DOI: 10.1186/s12882-019-1579-4
Abstract: BackgroundLiddle syndrome is a monogenic disease with autosomal dominant inheritance. Basic characteristics of this disease are hypertension, reduced concentration of aldosterone and renin activity, as well as increased excretion of potassium leading to low level… read more here.
Keywords: epithelial sodium; sodium channel; hypertension; liddle syndrome ... See more keywords
Hypertension and human immunodeficiency virus: A paradigm for epithelial sodium channels?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.968184
Abstract: Hypertension is a risk factor for end organ damage and death and is more common in persons with HIV compared to the general population. Several mechanisms have been studied in the pathogenesis of hypertension. Current… read more here.
Keywords: hypertension human; hypertension; immunodeficiency virus; sodium ... See more keywords