Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.10.097
Abstract: SUMMARY The epithelial-specific splicing regulators Esrp1 and Esrp2 are required for mammalian development, including establishment of epidermal barrier functions. However, the mechanisms by which Esrp ablation causes defects in epithelial barriers remain undefined. We determined… read more here.
Keywords: arhgef11; epithelial tight; tight junction; junction integrity ... See more keywords
Cis-Nerolidol Inhibits MAP Kinase and NF-κB Signaling Pathways and Prevents Epithelial Tight Junction Dysfunction in Colon Inflammation: In Vivo and In Vitro Studies
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28072982
Abstract: Inflammation of the GI tract leads to compromised epithelial barrier integrity, which increases intestine permeability. A compromised intestinal barrier is a critical event that leads to microbe entry and promotes inflammatory responses. Inflammatory bowel diseases… read more here.
Keywords: tight junction; epithelial tight; junction; signaling pathways ... See more keywords
Benzo[a]pyrene aggravated ovalbumin-induced epithelial tight junction disruption via ROS driven-NLRP3/Caspase-1 signaling pathway in asthmatic mice
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2025.5573
Abstract: Air pollutants contribute to the occurrence and development of asthma by impairing the airway epithelial barrier. However, underlying molecular mechanisms remain unknown. The present study investigated whether co-exposure to the air pollutant benzo[a]pyrene (BaP) and… read more here.
Keywords: junction disruption; epithelial tight; junction; tight junction ... See more keywords