131‐Oxophorbine protopheophorbide A from Ziziphus lotus as a novel mesenchymal‐epithelial transition factor receptor inhibitory lead for the control of breast tumor growth in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22874
Abstract: The failure of chemotherapy especially in triple negative breast cancer (TNBC) patients has been correlated with the overexpression of the mesenchymal‐epithelial transition factor (c‐Met) receptor. Thus, the hepatocyte growth factor (HGF)/c‐Met signaling axis has gained… read more here.
Keywords: epithelial transition; transition factor; mesenchymal epithelial; factor ... See more keywords
Mesenchymal–epithelial transition in development and reprogramming
Sign Up to like & getrecommendations! Published in 2019 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0195-z
Abstract: During organogenesis, epithelial cells can give rise to mesenchymal cells through epithelial–mesenchymal transition. The reverse process, mesenchymal–epithelial transition (MET), can similarly generate epithelial cells. Transitions between epithelial and mesenchymal states are also critical for the… read more here.
Keywords: epithelial transition; transition; development reprogramming; transition development ... See more keywords
Bone Vascular Niche E-selectin Induces Mesenchymal-Epithelial Transition and Wnt Activation in Cancer Cells to Promote Bone Metastasis
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DOI: 10.1038/s41556-019-0309-2
Abstract: How disseminated tumour cells engage specific stromal components in distant organs for survival and outgrowth is a critical but poorly understood step of the metastatic cascade. Previous studies have demonstrated the importance of the epithelial–mesenchymal… read more here.
Keywords: epithelial transition; transition; metastasis; bone ... See more keywords
Correlation analysis of mesenchymal–epithelial transition factor protein and human epidermal growth receptor 2 protein expression in 1479 cases of lung adenocarcinoma in China
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DOI: 10.1111/1759-7714.12595
Abstract: To investigate the correlation between mesenchymal–epithelial transition factor (C‐Met) and human epidermal growth receptor 2 (HER2) protein expression in primary lung adenocarcinoma tissues. read more here.
Keywords: protein; epithelial transition; transition factor; human epidermal ... See more keywords
Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aax7525
Abstract: Phospholipid-dependent regulation of NF-κB contributes to mesenchymal-to-epithelial transition in pluripotency acquisition. Metabolic reprogramming has emerged as a key regulator of cell fate decisions. Roles of glucose and amino acid metabolism have been extensively documented, whereas… read more here.
Keywords: epithelial transition; cdp etn; pluripotency; mesenchymal epithelial ... See more keywords
Hybrid-based drug design of 1,2,3-triazole-pyrimidine-hybrid derivatives: Efficient inhibiting agents of mesenchymal–epithelial transition factor reducing gastric cancer cell growth
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Chemical Research"
DOI: 10.1177/1747519819898354
Abstract: Anti-gastric cancer activity of 18 synthesized compounds was studied using theoretical and computational method. The studied compounds were docked against mesenchymal–epithelial transition factor (PDB ID: 2wgj) and the obtained scoring was compared with the standard… read more here.
Keywords: gastric cancer; epithelial transition; transition factor; mesenchymal epithelial ... See more keywords
The mechanisms of colorectal cancer cell mesenchymal-epithelial transition induced by hepatocyte exosome-derived miR-203a-3p
Sign Up to like & getrecommendations! Published in 2021 at "BMC Cancer"
DOI: 10.1186/s12885-021-08419-x
Abstract: Background Liver metastasis is the most common cause of death in patients with colorectal cancer (CRC). Phosphatase of regenerating liver-3 induces CRC metastasis by epithelial-to-mesenchymal transition, which promotes CRC cell liver metastasis. Mesenchymal-to-epithelial transition (MET),… read more here.
Keywords: epithelial transition; mir 203a; colorectal cancer; mesenchymal epithelial ... See more keywords
Nucleolar stress regulates stromal-epithelial transition via NPM1 during decidualization.
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DOI: 10.1530/rep-20-0051
Abstract: Embryo implantation and decidualization are crucial steps during early pregnancy. We recently showed that nucleolar stress is involved in embryo implantation. This study was to explore whether nucleolar stress participates in mouse and human decidualization.… read more here.
Keywords: epithelial transition; stromal epithelial; nucleolar stress; stress ... See more keywords
Narrative review: mesenchymal-epithelial transition inhibitors-meeting their target.
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DOI: 10.21037/tlcr-20-588
Abstract: Genetic alterations in mesenchymal-epithelial transition (MET) are commonly found in solid tumors, especially in non-small cell lung cancer (NSCLC). However, agents targeting MET have not progressed until recently. Advancements in our understanding of the role… read more here.
Keywords: narrative review; epithelial transition; target; review mesenchymal ... See more keywords