Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2017.1351949
Abstract: ABSTRACT Introduction: The mammalian SPS1-related proline/alanine-rich serine-threonine kinase SPAK (STK39) modulates ion transport across and between epithelial cells in response to environmental stimuli such osmotic stress and inflammation. Research over the last decade has established… read more here.
Keywords: kinase; spak kinase; targeting spak; epithelial transport ... See more keywords
Albumin Stimulates Epithelial Na+ Transport and Barrier Integrity by Activating the PI3K/AKT/SGK1 Pathway
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DOI: 10.3390/ijms23158823
Abstract: Albumin is a major serum protein and is frequently used as a cell culture supplement. It is crucially involved in the regulation of osmotic pressure and distribution of fluid between different compartments. Alveolar epithelial Na+… read more here.
Keywords: epithelial transport; transport; transport barrier; barrier integrity ... See more keywords