Hyperglycemia-reduced NAD+ biosynthesis impairs corneal epithelial wound healing in diabetic mice.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2020.154402
Abstract: OBJECTIVE Nicotinamide adenine dinucleotide (NAD) is an essential molecule participating in multiple physiological and pathophysiological processes. In diabetic cornea, the NAD+-consuming enzyme SIRT1 was down-regulated and contributed to the delayed wound healing. However, the impact… read more here.
Keywords: wound healing; epithelial wound; corneal epithelial; nad biosynthesis ... See more keywords
Netrin-1 promotes diabetic corneal wound healing through molecular mechanisms mediated via the adenosine 2B receptor
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24506-9
Abstract: Netrins are secreted chemoattractants with the roles in axon guidance, cell migration and epithelial plasticity. In the present study, we investigated the roles of netrin-1 in the regulation of corneal epithelial wound healing, inflammation response… read more here.
Keywords: wound healing; corneal epithelial; adenosine receptor; epithelial wound ... See more keywords
Ginsenoside Rb1 promotes intestinal epithelial wound healing through extracellular signal‐regulated kinase and Rho signaling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.14532
Abstract: Daikenchuto, a traditional Japanese herbal medicine, has been reported to exhibit anti‐inflammatory effects against intestinal inflammation. However, whether daikenchuto has a therapeutic effect against intestinal mucosal injuries remains unclear. Thus, the aim of this study… read more here.
Keywords: wound healing; intestinal epithelial; promotes intestinal; ginsenoside rb1 ... See more keywords
Interleukin-6 and lactate dehydrogenase expression in a novel ex vivo rocking model of equine corneal epithelial wound healing.
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary ophthalmology"
DOI: 10.1111/vop.12935
Abstract: PURPOSE To establish a physiologically relevant ex vivo model of equine corneal epithelial wound healing. METHODS Fourteen equine corneas were randomly assigned to one of two groups: wounded (n = 8) or unwounded (n = 6) controls. In the… read more here.
Keywords: wound healing; vivo; corneal epithelial; model ... See more keywords
Cigarette Smoke Impairs Airway Epithelial Wound Repair: Role of Modulation of Epithelial-Mesenchymal Transition Processes and Notch-1 Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11102018
Abstract: Cigarette smoke (CS) induces oxidative stress and chronic inflammation in airway epithelium. It is a major risk factor for respiratory diseases, characterized by epithelial injury. The impact of CS on airway epithelial repair, which involves… read more here.
Keywords: cigarette smoke; airway epithelial; wound repair; epithelial wound ... See more keywords
Effects of Selective Peroxisome Proliferator Activated Receptor Agonists on Corneal Epithelial Wound Healing
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14020088
Abstract: The effects of each subtype-selective peroxisome proliferator activated receptor (PPAR) agonist (α, β/δ, γ) on corneal epithelial wound healing were investigated using a rat corneal alkali burn model. After the alkali burn, each PPAR agonist… read more here.
Keywords: peroxisome proliferator; proliferator activated; corneal epithelial; selective peroxisome ... See more keywords
A Novel Ferroptosis Inhibitor UAMC-3203, a Potential Treatment for Corneal Epithelial Wound
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15010118
Abstract: Corneal wound, associated with pain, impaired vision, and even blindness, is the most common ocular injury. In this study, we investigated the effect of a novel ferroptosis inhibitor, UAMC-3203 (10 nM–50 µM), in corneal epithelial… read more here.
Keywords: uamc 3203; corneal epithelial; corneal; epithelial wound ... See more keywords