Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice
Sign Up to like & getrecommendations! Published in 2021 at "Mucosal Immunology"
DOI: 10.1038/s41385-021-00381-y
Abstract: The gut epithelium is a critical protective barrier. Its NAIP/NLRC4 inflammasome senses infection by Gram-negative bacteria, including Salmonella Typhimurium (S.Tm) and promotes expulsion of infected enterocytes. During the first ~12–24 h, this reduces mucosal S.Tm loads… read more here.
Keywords: naip nlrc4; barrier; autonomous naip; epithelium autonomous ... See more keywords