Microstructure dependent binding of pigment epithelium derived factor (PEDF) to type I collagen fibrils.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2017.06.001
Abstract: Pigment epithelium derived factor (PEDF) is a multifunctional extracellular protein. In addition to its known anti-angiogenic and neurotrophic roles in collagen rich tissues, PEDF is thought to be involved in collagen fibril assembly due to… read more here.
Keywords: collagen; collagen fibrils; epithelium derived; pedf ... See more keywords
Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2016.09.036
Abstract: Pigment epithelium-derived factor (PEDF) expression is downregulated in the kidneys of diabetic rats, and delivery of PEDF suppressed renal fibrotic factors in these animals. PEDF has multiple functions including anti-angiogenic, anti-inflammatory and antifibrotic activities. Since… read more here.
Keywords: tubule epithelial; epithelium derived; pedf; pigment epithelium ... See more keywords
Changes in serum pigment epithelium-derived factor levels after kidney transplantation in patients with end-stage renal disease
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2106243
Abstract: Abstract Background Pigment epithelium-derived factor (PEDF) is a serin protease inhibitor and a potent inhibitor of angiogenesis. Its serum level has significant associations with metabolic parameters. However, little is known about the association between PEDF… read more here.
Keywords: transplantation patients; pigment epithelium; derived factor; transplantation ... See more keywords
Pigment Epithelium-Derived Factor-Loaded PEGylated Nanoparticles as a New Antiangiogenic Therapy for Neovascularization
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Research"
DOI: 10.1155/2022/1193760
Abstract: Background Pathological neovascularization, which involves a disruption in the balance between angiogenic and antiangiogenic factors under pathological conditions, is the basis of many intraocular diseases. Pigment epithelium-derived factor (PEDF) is a potent natural, endogenous inhibitor… read more here.
Keywords: pedf; peg pedf; pigment epithelium; factor ... See more keywords
Pigment Epithelium-Derived Factor Protects Retinal Neural Cells and Prevents Pathological Angiogenesis in an Ex Vivo Ischemia Model
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/4199394
Abstract: Ocular ischemia/hypoxia is a severe problem in ophthalmology that can cause vision impairment and blindness. However, little is known about the changes occurring in the existing fully formed choroidal blood vessels. We developed a new… read more here.
Keywords: ischemia; ischemia hypoxia; pigment epithelium; pathological angiogenesis ... See more keywords
Pigment epithelium-derived factor downregulation in oestrogen receptor positive breast cancer bone metastases is associated with menopause
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Endocrinology"
DOI: 10.2139/ssrn.4166953
Abstract: Pigment epithelium-derived factor (PEDF) has a critical role in bone development and anti-tumour function in breast cancer (BC). As the expression and role of PEDF in BC bone metastases is unknown, we aimed to characterise… read more here.
Keywords: pedf; bone; pigment epithelium; factor ... See more keywords
Pigment epithelium-derived factor is an interleukin-6 antagonist in the RPE: Insight of structure-function relationships
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1045613
Abstract: Retinal and choroidal inflammatory lesions increase the levels of the pro-inflammatory cytokine interleukin-6 (IL-6). Pigment epithelium-derived factor (PEDF) has anti-inflammatory properties, but it is not known if it can prevent the production of IL-6 by… read more here.
Keywords: pedf; rpe; epithelium; pigment epithelium ... See more keywords
Expression of pigment epithelium-derived factor in psoriasis, verrucae, squamous cell carcinoma and normal skin: An immunohistochemical study
Sign Up to like & getrecommendations! Published in 2020 at "Indian Journal of Dermatology, Venereology and Leprology"
DOI: 10.4103/ijdvl.ijdvl_396_19
Abstract: Background: Preservation of homeostasis status in the skin needs an equilibrium of keratinocyte proliferation, differentiation, necrosis and apoptosis. Disturbance of these regulatory mechanisms may lead to keratinocyte neoplastic and hyperproliferative diseases. Pigment epithelium-derived factor is… read more here.
Keywords: squamous cell; epithelium derived; normal skin; pigment epithelium ... See more keywords