LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "epitope" as a keyword



Creation of a novel CRISPR‐generated allele to express HA epitope‐tagged C1QL1 and improved methods for its detection at synapses

Sign Up to like & get
recommendations! Published in 2024 at "FEBS Letters"

DOI: 10.1002/1873-3468.14946

Abstract: C1QL1 is expressed in a subset of cells in the brain and likely has pleiotropic functions, including the regulation of neuron‐to‐neuron synapses. Research progress on C1QL proteins has been slowed by a dearth of available… read more here.

Keywords: novel crispr; epitope tagged; creation novel; generated allele ... See more keywords

A Biologically Informed Vision-Guided Framework for Interpretable T Cell Receptor-Epitope Binding Prediction.

Sign Up to like & get
recommendations! Published in 2025 at "Advanced science"

DOI: 10.1002/advs.202512544

Abstract: Accurate identification of the interactions between T‐cell receptors (TCRs) and antigenic epitopes presented by major histocompatibility complex (MHC) molecules is fundamental to advancing cancer immunotherapy. Nevertheless, predictive modeling of TCR–epitope binding remains challenging, as existing… read more here.

Keywords: vision guided; biologically informed; informed vision; epitope binding ... See more keywords

Epitope Screening Using Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS): An Accelerated Workflow for Evaluation of Lead Monoclonal Antibodies.

Sign Up to like & get
recommendations! Published in 2021 at "Biotechnology journal"

DOI: 10.1002/biot.202100358

Abstract: BACKGROUND Epitope mapping is an increasingly important aspect of biotherapeutic and vaccine development. Recent advances in therapeutic antibody design and production have enabled candidate mAbs to be identified at a rapidly increasing rate, resulting in… read more here.

Keywords: mass spectrometry; exchange mass; epitope screening; hydrogen deuterium ... See more keywords

Pro region engineering of nerve growth factor by deep mutational scanning enables a yeast platform for conformational epitope mapping of anti-NGF monoclonal antibodies.

Sign Up to like & get
recommendations! Published in 2018 at "Biotechnology and bioengineering"

DOI: 10.1002/bit.26606

Abstract: Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti-NGF monoclonal antibodies (mAbs) that function by antagonizing NGF downstream signaling are leading drug candidates for non-opioid pain relief. To… read more here.

Keywords: nerve growth; pro region; anti ngf; epitope ... See more keywords

Pro region engineering of nerve growth factor by deep mutational scanning enables a yeast platform for conformational epitope mapping of anti‐NGF monoclonal antibodies

Sign Up to like & get
recommendations! Published in 2018 at "Biotechnology and Bioengineering"

DOI: 10.1002/bit.26706

Abstract: Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti‐NGF monoclonal antibodies (mAbs) that function by antagonizing NGF downstream signaling are leading drug candidates for non‐opioid pain relief. To… read more here.

Keywords: nerve growth; pro region; anti ngf; epitope ... See more keywords

An epitope‐directed antibody affinity maturation system utilizing mammalian cell survival as readout

Sign Up to like & get
recommendations! Published in 2019 at "Biotechnology and Bioengineering"

DOI: 10.1002/bit.26965

Abstract: Upon developing therapeutically potent antibodies, there are significant requirements, such as increasing their affinity, regulating their epitope, and using native target antigens. Many antibody selection systems, such as a phage display method, have been developed,… read more here.

Keywords: cell; system; affinity; antibody affinity ... See more keywords

Epitope delimitation: A new method for defining epitopes of human IgG‐reactive antigenic peptides based on rabbit‐recognized epitope motifs

Sign Up to like & get
recommendations! Published in 2024 at "Journal of Medical Virology"

DOI: 10.1002/jmv.29388

Abstract: The use of precise epitope peptides as antigens is essential for accurate serological diagnosis of viral‐infected individuals, but now it remains an unsolvable problem for mapping precise B cell epitopes (BCEs) recognized by human serum.… read more here.

Keywords: human igg; epitope delimitation; igg reactive; rabbit ... See more keywords

A public, cross-reactive glycoprotein epitope confounds Ebola virus serology

Sign Up to like & get
recommendations! Published in 2024 at "Journal of medical virology"

DOI: 10.1002/jmv.29946

Abstract: Ebola disease (EBOD) in humans is a severe disease caused by at least four related viruses in the genus Orthoebolavirus, most often by the eponymous Ebola virus. Due to human‐to‐human transmission and incomplete success in… read more here.

Keywords: cross reactive; virus; epitope; serology ... See more keywords

Epitope‐directed anti‐SARS‐CoV‐2 scFv engineered against the key spike protein region could block membrane fusion

Sign Up to like & get
recommendations! Published in 2023 at "Protein Science"

DOI: 10.1002/pro.4575

Abstract: The newly emerged SARS‐CoV‐2 causing coronavirus disease (COVID‐19) resulted in >500 million infections. A great deal about the molecular processes of virus infection in the host is getting uncovered. Two sequential proteolytic cleavages of viral… read more here.

Keywords: spike; epitope; spike protein; site ... See more keywords

Dynamics of virus and immune response in multi-epitope network

Sign Up to like & get
recommendations! Published in 2018 at "Journal of Mathematical Biology"

DOI: 10.1007/s00285-018-1224-z

Abstract: The host immune response can often efficiently suppress a virus infection, which may lead to selection for immune-resistant viral variants within the host. For example, during HIV infection, an array of CTL immune response populations… read more here.

Keywords: network; response; dynamics virus; virus immune ... See more keywords

Identification of a conserved conformational epitope in the VP2 protein of foot-and-mouth disease virus

Sign Up to like & get
recommendations! Published in 2017 at "Archives of Virology"

DOI: 10.1007/s00705-017-3304-6

Abstract: Foot-and-mouth disease (FMD), caused by foot-and-mouth disease virus (FMDV), is a highly contagious infectious disease that affects domestic and wild cloven-hoofed animals worldwide. VP2 is a structural protein of FMDV. In this study, a potent… read more here.

Keywords: foot mouth; vp2 protein; conformational epitope; epitope ... See more keywords