Epitope Screening Using Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS): An Accelerated Workflow for Evaluation of Lead Monoclonal Antibodies.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology journal"
DOI: 10.1002/biot.202100358
Abstract: BACKGROUND Epitope mapping is an increasingly important aspect of biotherapeutic and vaccine development. Recent advances in therapeutic antibody design and production have enabled candidate mAbs to be identified at a rapidly increasing rate, resulting in… read more here.
Keywords: mass spectrometry; exchange mass; epitope screening; hydrogen deuterium ... See more keywords
Pro region engineering of nerve growth factor by deep mutational scanning enables a yeast platform for conformational epitope mapping of anti-NGF monoclonal antibodies.
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.26606
Abstract: Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti-NGF monoclonal antibodies (mAbs) that function by antagonizing NGF downstream signaling are leading drug candidates for non-opioid pain relief. To… read more here.
Keywords: nerve growth; pro region; anti ngf; epitope ... See more keywords
Pro region engineering of nerve growth factor by deep mutational scanning enables a yeast platform for conformational epitope mapping of anti‐NGF monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26706
Abstract: Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti‐NGF monoclonal antibodies (mAbs) that function by antagonizing NGF downstream signaling are leading drug candidates for non‐opioid pain relief. To… read more here.
Keywords: nerve growth; pro region; anti ngf; epitope ... See more keywords
An epitope‐directed antibody affinity maturation system utilizing mammalian cell survival as readout
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26965
Abstract: Upon developing therapeutically potent antibodies, there are significant requirements, such as increasing their affinity, regulating their epitope, and using native target antigens. Many antibody selection systems, such as a phage display method, have been developed,… read more here.
Keywords: cell; system; affinity; antibody affinity ... See more keywords
Epitope‐directed anti‐SARS‐CoV‐2 scFv engineered against the key spike protein region could block membrane fusion
Sign Up to like & getrecommendations! Published in 2023 at "Protein Science"
DOI: 10.1002/pro.4575
Abstract: The newly emerged SARS‐CoV‐2 causing coronavirus disease (COVID‐19) resulted in >500 million infections. A great deal about the molecular processes of virus infection in the host is getting uncovered. Two sequential proteolytic cleavages of viral… read more here.
Keywords: spike; epitope; spike protein; site ... See more keywords
Dynamics of virus and immune response in multi-epitope network
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Mathematical Biology"
DOI: 10.1007/s00285-018-1224-z
Abstract: The host immune response can often efficiently suppress a virus infection, which may lead to selection for immune-resistant viral variants within the host. For example, during HIV infection, an array of CTL immune response populations… read more here.
Keywords: network; response; dynamics virus; virus immune ... See more keywords
Identification of a conserved conformational epitope in the VP2 protein of foot-and-mouth disease virus
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Virology"
DOI: 10.1007/s00705-017-3304-6
Abstract: Foot-and-mouth disease (FMD), caused by foot-and-mouth disease virus (FMDV), is a highly contagious infectious disease that affects domestic and wild cloven-hoofed animals worldwide. VP2 is a structural protein of FMDV. In this study, a potent… read more here.
Keywords: foot mouth; vp2 protein; conformational epitope; epitope ... See more keywords
Development of Avian Avulavirus 1 Epitope-Based Vaccine Pattern Based on Epitope Prediction and Molecular Docking Analysis: An Immunoinformatic Approach
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-019-09952-x
Abstract: Fusion (F) and Hemagglutinin-neuraminidase (HN) glycoproteins of Newcastle disease virus containing important epitopes play crucial role in stimulation of humoral and cell-mediated immunity of the host. In the present study we analyzed and compared genetic… read more here.
Keywords: docking analysis; epitope; molecular docking; epitope prediction ... See more keywords
Computational Design of a Multi-epitope Vaccine Against Clostridium chauvoei: An Immunoinformatics Approach
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-021-10279-9
Abstract: Blackleg is an infectious disease of animals that is commonly caused by Clostridium chauvoei and characterized by localized muscle necrosis. In this study, proteome-mining and immunoinformatics approaches were applied to identify novel antigenic proteins and… read more here.
Keywords: clostridium chauvoei; vaccine; epitope; epitope vaccine ... See more keywords
Depotentiation of Long-Term Potentiation Is Associated with Epitope-Specific Tau Hyper-/Hypophosphorylation in the Hippocampus of Adult Rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1224-x
Abstract: It is well-known that some kinases which are involved in the induction of synaptic plasticity probably modulate tau phosphorylation. However, how depression of potentiated synaptic strength contributes to tau phosphorylation is unclear because of the… read more here.
Keywords: tau; hippocampus; epitope specific; long term ... See more keywords
In silico identification and characterization of common epitope-based peptide vaccine for Nipah and Hendra viruses.
Sign Up to like & getrecommendations! Published in 2017 at "Asian Pacific journal of tropical medicine"
DOI: 10.1016/j.apjtm.2017.06.016
Abstract: OBJECTIVE To explore a common B- and T-cell epitope-based vaccine that can elicit an immune response against encephalitis causing genus Henipaviruses, Hendra virus (HeV) and Nipah virus (NiV). METHODS Membrane proteins F, G and M… read more here.
Keywords: cell epitopes; cell; hev niv; epitope based ... See more keywords