Epitope mapping of neutralising anti‐SARS‐CoV‐2 monoclonal antibodies: Implications for immunotherapy and vaccine design
Sign Up to like & getrecommendations! Published in 2022 at "Reviews in Medical Virology"
DOI: 10.1002/rmv.2347
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of the coronavirus disease 2019 (COVID‐19) pandemic. This disease has currently affected more than 346 million people and resulted in more than 5.5 million… read more here.
Keywords: neutralising anti; anti sars; monoclonal antibodies; epitope mapping ... See more keywords
Epitope mapping of antibodies in C-reactive protein assay kits by hydrogen-deuterium exchange mass spectrometry explains differential results across kits
Sign Up to like & getrecommendations! Published in 2022 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-022-04029-z
Abstract: C-Reactive protein (CRP) is an important marker for in vitro diagnosis (IVD) of inflammation. However, CRP immunoturbidimetric kits from different manufacturers exhibit inconsistency in evaluation, making clinical diagnosis challenging. The use of immunological methods in… read more here.
Keywords: reactive protein; epitope mapping; exchange mass; hydrogen deuterium ... See more keywords
Epitope mapping of commercial antibodies that detect myocilin.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental eye research"
DOI: 10.1016/j.exer.2018.05.002
Abstract: The presence of myocilin is often used in the process of validating trabecular meshwork (TM) cells and eye tissues, but the antibody reagents used for detection are poorly characterized. Indeed, for over a century, researchers… read more here.
Keywords: epitope mapping; myocilin; mapping commercial; detect myocilin ... See more keywords
Biosensor-based epitope mapping of antibodies targeting the hemagglutinin and neuraminidase of influenza A virus.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2018.07.007
Abstract: Characterization of the epitopes on antigen recognized by monoclonal antibodies (mAb) is useful for the development of therapeutic antibodies, diagnostic tools, and vaccines. Epitope mapping also provides functional information for sequence-based repertoire analysis of antibody… read more here.
Keywords: epitope mapping; hemagglutinin neuraminidase; mapping antibodies; based epitope ... See more keywords
Detailed epitope mapping of SARS-CoV-2 nucleoprotein reveals specific immunoresponse in cats and dogs housed with COVID-19 patients
Sign Up to like & getrecommendations! Published in 2022 at "Research in Veterinary Science"
DOI: 10.1016/j.rvsc.2021.12.020
Abstract: Since the initial emergence in December 2019, the novel Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been reported in over 200 countries, representing an unprecedented challenge related to disease control worldwide. In this context, cases of… read more here.
Keywords: housed covid; mapping sars; sars cov; cov nucleoprotein ... See more keywords
Fine epitope mapping of the CD19 extracellular domain promotes design.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00808
Abstract: The B cell surface protein CD19 is present throughout the cell life cycle and uniformly expressed in leukemias making it a target for chimeric antigen receptor engineered immune cell therapy. Identifying the sequence dependence of… read more here.
Keywords: cd19; epitope mapping; antibody; cd19 extracellular ... See more keywords
Epitope Mapping and Binding Assessment by Solid-State NMR Provide a Way for the Development of Biologics under the Quality by Design Paradigm
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c03232
Abstract: Multispecific biologics are an emerging class of drugs, in which antibodies and/or proteins designed to bind pharmacological targets are covalently linked or expressed as fusion proteins to increase both therapeutic efficacy and safety. Epitope mapping… read more here.
Keywords: mapping binding; solid state; epitope mapping; state nmr ... See more keywords
Epitope mapping of diverse influenza Hemagglutinin drug candidates using HDX-MS
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41179-0
Abstract: Epitope characterization is critical for elucidating the mechanism of action of drug candidates. However, traditional high-resolution epitope mapping techniques are not well suited for screening numerous drug candidates recognizing a similar target. Here, we use… read more here.
Keywords: drug; hdx epitope; epitope mapping; drug candidates ... See more keywords
Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold
Sign Up to like & getrecommendations! Published in 2023 at "mAbs"
DOI: 10.1080/19420862.2023.2175311
Abstract: ABSTRACT Delineating the precise regions on an antigen that are targeted by antibodies has become a key step for the development of antibody therapeutics. X-ray crystallography and cryogenic electron microscopy are considered the gold standard… read more here.
Keywords: lamp antibodies; lamp; human lamp; deep mutational ... See more keywords
Epitope Mapping of the Antibody Response Against the Envelope Proteins of the Feline Foamy Virus.
Sign Up to like & getrecommendations! Published in 2017 at "Viral immunology"
DOI: 10.1089/vim.2016.0156
Abstract: Foamy viruses (FV) are retroviruses that infect several species without pathological signs, but induce substantial antibody responses in the infected host. In the case of feline FV (FFV), antibodies against Gag, Bet, and Env have… read more here.
Keywords: mapping antibody; epitope mapping; antibody; antibody response ... See more keywords
What are oxytocin assays measuring? Epitope mapping, metabolites, and comparisons of wildtype & knockout mouse urine
Sign Up to like & getrecommendations! Published in 2022 at "Psychoneuroendocrinology"
DOI: 10.1101/2022.03.03.482682
Abstract: Oxytocin has become a popular analyte in behavioral endocrinology in recent years, due in part to its roles in social behavior, stress physiology, and cognition. Urine samples have the advantage of being non-invasive and minimally… read more here.
Keywords: oxytocin; epitope; interference; cross reactivity ... See more keywords