Generation of Variability-Free Reference Proteomes from Pathogenic Organisms for Epitope-Vaccine Design.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0389-5_13
Abstract: Many pathogenic organisms have an inherent ability to rapidly evolve into new variants, which enables them to escape previously existing immune responses. Vaccine design strategies should be aimed to counteract such variability, targeting the conserved… read more here.
Keywords: vaccine design; variability; variability free; pathogenic organisms ... See more keywords
Computational Design of a Multi-epitope Vaccine Against Clostridium chauvoei: An Immunoinformatics Approach
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-021-10279-9
Abstract: Blackleg is an infectious disease of animals that is commonly caused by Clostridium chauvoei and characterized by localized muscle necrosis. In this study, proteome-mining and immunoinformatics approaches were applied to identify novel antigenic proteins and… read more here.
Keywords: clostridium chauvoei; vaccine; epitope; epitope vaccine ... See more keywords
Multi-epitope vaccine against cystic echinococcosis using immunodominant epitopes from EgA31 and EgG1Y162 antigens
Sign Up to like & getrecommendations! Published in 2020 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2020.100464
Abstract: Abstract Cystic echinococcosis (CE) is a near-cosmopolitan public health concern, especially in developing countries. Parasite ova shed via definitive host feces are responsible for livestock and occasionally human infection, leading to hydatid cysts. Immunization using… read more here.
Keywords: cystic echinococcosis; ega31 egg1y162; egg1y162 antigens; epitope vaccine ... See more keywords
A vaccine built from potential immunogenic pieces derived from the SARS-CoV-2 spike glycoprotein: A computational approximation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunological Methods"
DOI: 10.1016/j.jim.2022.113216
Abstract: Coronavirus Disease 2019 (COVID-19) represents a new global threat demanding a multidisciplinary effort to fight its etiological agent—severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this regard, immunoinformatics may aid to predict prominent immunogenic regions… read more here.
Keywords: multi epitope; sars cov; epitope vaccine; vaccine built ... See more keywords
Fermentation, purification and immunogenicity of a recombinant tumor multi-epitope vaccine, VBP3.
Sign Up to like & getrecommendations! Published in 2020 at "Protein expression and purification"
DOI: 10.1016/j.pep.2020.105658
Abstract: The recombinant multi-epitope vaccine called VBP3 is designed to suppress tumor growth and angiogenesis through targeting both basic fibroblast growth factor (bFGF) and vascular endothelial growth factor A (VEGFA). We are aiming to produce VBP3… read more here.
Keywords: tumor; fermentation; vaccine; vbp3 ... See more keywords
Multi-epitope-Based Vaccine Designed by Targeting Cytoadherence Proteins of Mycoplasma gallisepticum
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c01032
Abstract: Mycoplasma gallisepticum causes chronic respiratory disease in chickens leading to large economic losses in the poultry industry, and the impacts remain to be a great challenge for a longer period. Among the other approaches, a… read more here.
Keywords: mycoplasma gallisepticum; epitope based; vaccine; epitope vaccine ... See more keywords
Designing a multi-epitope vaccine candidate to combat MERS-CoV by employing an immunoinformatics approach
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92176-1
Abstract: Currently, no approved vaccine is available against the Middle East respiratory syndrome coronavirus (MERS-CoV), which causes severe respiratory disease. The spike glycoprotein is typically considered a suitable target for MERS-CoV vaccine candidates. A computational strategy… read more here.
Keywords: vaccine candidate; vaccine; mers cov; epitope vaccine ... See more keywords
Design of a multi-epitope vaccine against SARS-CoV-2: immunoinformatic and computational methods
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d1ra06532g
Abstract: SARS-CoV-2 infections have spread throughout the world and became a rapidly emerging public health issue. The immunoinformatics approach was applied to design a potent multi-epitope vaccine against this deadly virus. read more here.
Keywords: design multi; multi epitope; epitope vaccine; sars cov ... See more keywords
Development of Multi-Epitope Vaccine constructs for Non-Small Cell Lung Cancer (NSCLC) Against USA Human Leukocyte Antigen Background: an Immunoinformatic approach toward future vaccine designing.
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on biological therapy"
DOI: 10.1080/14712598.2021.1981285
Abstract: OBJECTIVES The design of peptide-based vaccines for cancer is a promising immunotherapy that can induce a cancer-specific cytotoxic response in tumor cells. METHODS Herein, we used the immunoinformatic approach in designing a multi-epitope vaccine targeting… read more here.
Keywords: immunoinformatic approach; vaccine constructs; cancer; epitope vaccine ... See more keywords
In silico design and immunoinformatics analysis of a universal multi-epitope vaccine against monkeypox virus
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0286224
Abstract: Monkeypox virus (MPXV) outbreaks have been reported in various countries worldwide; however, there is no specific vaccine against MPXV. In this study, therefore, we employed computational approaches to design a multi-epitope vaccine against MPXV. Initially,… read more here.
Keywords: multi epitope; epitope vaccine; vaccine; monkeypox virus ... See more keywords
Designing and Characterization of Tregitope-Based Multi-Epitope Vaccine Against Multiple Sclerosis: An Immunoinformatic Approach.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug safety"
DOI: 10.2174/1574886317666220429105439
Abstract: BACKGROUND Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). It is widely accepted that the development and progression of MS result from aberrant activation of potentially encephalitogenic reactive-T cells… read more here.
Keywords: epitope vaccine; multiple sclerosis; multi epitope; tregitope based ... See more keywords