Exploring the Distinct Binding and Activation Mechanisms for Different CagA Oncoproteins and SHP2 by Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26040837
Abstract: CagA is a major virulence factor of Helicobacter pylori. H. pylori CagA is geographically subclassified into East Asian CagA and Western CagA, which are characterized by the presence of a EPIYA-D or EPIYA-C segment. The… read more here.
Keywords: domain shp2; caga; key helix; epiya ... See more keywords
The EPIYA-ABCC motif of Helicobacter pylori cagA gene and gastric carcinogenesis in Casablanca population
Sign Up to like & getrecommendations! Published in 2022 at "African Health Sciences"
DOI: 10.4314/ahs.v22i1.66
Abstract: Background H. pylori infection induce atrophic gastritis (AG) and intestinal metaplasia (IM) that can lead to gastric cancer (GC). The severity of gastric lesions is related to H. pylori genetic diversity. The oncogenic potential of… read more here.
Keywords: caga gene; epiya; pylori caga; abcc motif ... See more keywords