Impact of eplerenone on major cardiovascular outcomes in patients with systolic heart failure according to baseline heart rate
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Research in Cardiology"
DOI: 10.1007/s00392-018-1410-4
Abstract: BackgroundIncreased resting heart rate is a risk factor for cardiovascular mortality and morbidity. Mineralocorticoid receptor antagonists (MRAs) have been shown to improve cardiac sympathetic nerve activity, reduce heart rate and attenuate left ventricular remodelling. Whether… read more here.
Keywords: heart rate; heart; eplerenone; heart failure ... See more keywords
Serum sodium and eplerenone use in patients with a myocardial infarction and left ventricular dysfunction or heart failure: insights from the EPHESUS trial
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Research in Cardiology"
DOI: 10.1007/s00392-021-01853-8
Abstract: Sodium changes are common in myocardial infarction (MI) complicated with left ventricular systolic dysfunction (LVSD) and/or heart failure (HF). Sodium handling is fine-tuned in the distal nephron, were eplerenone exhibits some of its pleotropic effects.… read more here.
Keywords: serum sodium; myocardial infarction; sodium; eplerenone ... See more keywords
Reply to: ‘Current perspectives on the use of eplerenone for chronic central serous chorioretinopathy’
Sign Up to like & getrecommendations! Published in 2021 at "Eye"
DOI: 10.1038/s41433-020-01327-7
Abstract: We thank Drs Xia and Hua for their interest in our work [1]. The authors cite two retrospective studies with smaller numbers of patients than our prospective randomised trial and no control groups to suggest… read more here.
Keywords: chronic central; trial; central serous; serous chorioretinopathy ... See more keywords
Development of eplerenone nano sono-crystals using factorial design: enhanced solubility and dissolution rate via anti solvent crystallization technique
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2022.2160985
Abstract: Abstract Objective The purpose of this work was to improve EP solubility by using a sono-crystalization approach to reduce particle size and hence, increase the dissolution rate. Significance Eplerenone (EP) is an antagonist of the… read more here.
Keywords: solubility dissolution; rate; eplerenone; dissolution rate ... See more keywords
Effect of the Nonsteroidal Mineralocorticoid Receptor Blocker, Esaxerenone, on Nocturnal Hypertension: A Post Hoc Analysis of the ESAX-HTN Study
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DOI: 10.1093/ajh/hpaa155
Abstract: Abstract BACKGROUND Nocturnal hypertension is an important phenotype of abnormal diurnal blood pressure (BP) variability and a known risk marker for target organ damage and cardiovascular events. This study aimed to assess the differential BP-lowering… read more here.
Keywords: nocturnal hypertension; post hoc; study; eplerenone ... See more keywords
A3067 Eplerenone inhibits the cell pyroptosis in contralateral kidney of UUO rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548095.91094.dd
Abstract: Objectives: To investigate the inhibitory effect of eplerenone, an aldosterone receptor blocker, on cell pyroptosis in contralateral kidney of UUO rats, and to elucidate the role of aldosterone in the process of unilateral renal injury-induced… read more here.
Keywords: uuo rats; contralateral kidney; eplerenone; kidney uuo ... See more keywords
The selective mineralocorticoid receptor antagonist eplerenone prevents decompensation of the liver in cirrhosis
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DOI: 10.1111/bph.14341
Abstract: The mineralocorticoid receptor (MR) contributes to fibrosis in various tissues, and MR antagonists, like eplerenone, are used to prevent fibrosis. The role of MR antagonists in hepatic fibrosis and cirrhosis is unknown. Here, we investigated… read more here.
Keywords: receptor antagonist; cirrhosis; mineralocorticoid receptor; eplerenone ... See more keywords
Eplerenone for the treatment of chronic central serous chorioretinopathy: 3-year clinical experience
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Ophthalmology"
DOI: 10.1136/bjophthalmol-2019-314047
Abstract: Background/aims The efficacy of mineralocorticoid receptor antagonist eplerenone to treat chronic central serous chorioretinopathy (CSCR) has been established. However, previous studies have been limited by small cohort size and short follow-up duration. This study aims… read more here.
Keywords: chronic central; year; central serous; serous chorioretinopathy ... See more keywords
OCT-A in chronic central serous chorioretinopathy treated with oral eplerenone and half-fluence photodynamic therapy: A comparative study
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Ophthalmology"
DOI: 10.1177/11206721221131129
Abstract: Purpose To evaluate retinal and choriocapillary vessel density (VD) changes in patients with chronic central serous chorioretinopathy (CSC) treated with half-fluence verteporfin photodynamic therapy (vPDT) or eplerenone, using optical coherence tomography angiography (OCTA). Methods Patients… read more here.
Keywords: eplerenone; group; serous chorioretinopathy; chronic central ... See more keywords
Functionality of retinal vessels in central serous retinopathy: A comparison between eplerenone and photodynamic therapy
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Ophthalmology"
DOI: 10.1177/11206721221145049
Abstract: Purpose To investigate retinal vessels functionality in patients with acute central serous chorioretinopathy (CSC) undergoing oral eplerenone or photodynamic therapy (PDT) using Retinal Vessel Analyzer (RVA) and Dynamic Vessel Analyzer (DVA), respectively. Methods Treatment naïve… read more here.
Keywords: oral eplerenone; eplerenone; retinal vessels; eplerenone photodynamic ... See more keywords
Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2018 at "BMC Pulmonary Medicine"
DOI: 10.1186/s12890-018-0604-x
Abstract: BackgroundAldosterone is a mineralocorticoid hormone critically involved in arterial blood pressure regulation. Although pharmacological aldosterone antagonism reduces mortality and morbidity among patients with severe left-sided heart failure, the contribution of aldosterone to the pathobiology of… read more here.
Keywords: arterial hypertension; pulmonary vascular; pulmonary arterial; eplerenone ... See more keywords