Class II HLA Eplet Mismatch Is a Risk Factor for De Novo Donor-Specific Antibody Development and Antibody-mediated Rejection in Kidney Transplantation Recipients.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.02.183
Abstract: OBJECTIVES We investigated the correlation between class II HLA epitope mismatch and antibody-mediated rejection (AMR) episodes in kidney transplant recipients. In patients with AMR, epitope mismatch was also examined for each class II HLA mismatch… read more here.
Keywords: class; antibody; hla; eplet ... See more keywords
HLA-DQ eplet mismatch load may identify kidney transplant patients eligible for tacrolimus withdrawal without donor-specific antibody formation after mesenchymal stromal cell therapy.
Sign Up to like & getrecommendations! Published in 2023 at "HLA"
DOI: 10.1111/tan.15008
Abstract: Recently, the randomized phase-II Triton study demonstrated that mesenchymal stromal cell (MSC) therapy facilitated early tacrolimus withdrawal in living donor kidney transplant recipients. The current sub-study analyzed formation of de novo donor-specific HLA antibodies (dnDSA)… read more here.
Keywords: hla eplet; hla; eplet; mismatch load ... See more keywords
Evaluating the Antigen and Eplet Accuracy of DQA1 Imputations With the HaploSFHI Two‐Field HLA Typing Inference Tool
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DOI: 10.1111/tan.70197
Abstract: Donor/recipient mismatched HLA antigens can lead to the production of Donor‐Specific Antibodies by the recipient, which are deleterious to organ transplants. The HLA‐DQ locus is the most frequent target, with both the DQ beta and… read more here.
Keywords: hla dqa1; hla; field hla; two field ... See more keywords
The Hunt for HLA‐DQ Allogeneic Eplets Is Not Over: Four New Ones, Including a Cross‐Chain Eplet
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DOI: 10.1111/tan.70386
Abstract: The target of an anti‐HLA antibody is an epitope on the surface of the antigen, and in particular the polymorphic eplet of its core, which contains one or a few polymorphic residues accessible to the… read more here.
Keywords: allogeneic eplets; hla; hunt hla; hla allogeneic ... See more keywords
Clinical relevance of HLA-DQ eplet mismatch and maintenance immunosuppression with risk of allosensitization after kidney transplant failure
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2024.1383220
Abstract: The optimal immunosuppression management in patients with a failed kidney transplant remains uncertain. This study analyzed the association of class II HLA eplet mismatches and maintenance immunosuppression with allosensitization after graft failure in a well… read more here.
Keywords: hla eplet; kidney transplant; immunosuppression; transplant failure ... See more keywords
Combined Analysis of HLA Class II Eplet Mismatch and Tacrolimus Levels for the Prediction of De Novo Donor Specific Antibody Development in Kidney Transplant Recipients
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137357
Abstract: We investigated whether HLA class II eplet mismatch was related to dnDSA development and analyzed its combined impact with tacrolimus levels for kidney transplantation outcomes. A total of 347 kidney transplants were included. HLA Matchmaker… read more here.
Keywords: hla class; development; eplet; dndsa ... See more keywords