Detection of a non-erythropoietic EPO, Neuro-EPO, in blood after intra-nasal administration in rat.
Sign Up to like & getrecommendations! Published in 2020 at "Drug testing and analysis"
DOI: 10.1002/dta.2924
Abstract: Non-erythropoietic erythropoietin (EPO) are investigated for their high anti-oxidant properties. A new drug candidate under clinical investigation to treat brain diseases is Neuro-EPO, produced by selecting EPO isoforms with low sialic acid content. Intra-nasal administration… read more here.
Keywords: administration; detection; neuro epo; epo ... See more keywords
Detection of De-N-Glycosylated EPO with SDS-PAGE: A Complementary Confirmation Procedure for Recombinant EPO in Blood Samples.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3324
Abstract: Frameshift variant c.577del in the EPO gene can result in the extension of the Amino Acid sequence of EPO by invalidating the termination codon. As the molecular weight of its encoded protein EPO (VAR-EPO) is… read more here.
Keywords: epo; complementary confirmation; blood samples; glycosylated epo ... See more keywords
C‐Terminal, but Not Intact, FGF23 and EPO Are Strongly Correlatively Elevated in Patients With Gain‐of‐Function Mutations in HIF2A: Clinical Evidence for EPO Regulating FGF23
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4195
Abstract: Fibroblast growth factor 23 (FGF23) is a key phosphate‐ and vitamin D‐regulating hormone. FGF23 circulates as an intact 251 amino acid protein or N‐ and C‐terminal degradation products. Hormone activity resides in the intact molecule,… read more here.
Keywords: fgf23; function mutations; intact fgf23; physiology ... See more keywords
Comparison of Misoprostol and Evening Primrose on Cervical Preparation Before Gynecological Surgery.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2253
Abstract: This study aimed to evaluate the efficacy and safety of evening primrose oil(EPO) for cervical ripening before gynecologic procedures and compare it to misoprostol. In this study,40 hysteroscopy, dilation and curettage (D&C) candidates were enrolled.… read more here.
Keywords: epo; evening primrose; misoprostol; group ... See more keywords
Development of a stable chemically cross-linked erythropoietin dimer for use in the quality control of erythropoietin therapeutic products
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-01768-4
Abstract: AbstractErythropoietin (EPO) is a glycoprotein hormone which promotes red cell replenishment and is also a global biotherapeutic medicine widely used to treat anaemia resulting, for example, from chemotherapy. Requirements of the European Pharmacopoeia stipulate that… read more here.
Keywords: chemically cross; stable chemically; cross linked; epo ... See more keywords
Long-term results of a pilot study evaluating hyperbaric oxygen therapy to improve umbilical cord blood engraftment
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3532-1
Abstract: Umbilical cord blood (UCB) transplantation is a promising option for hematopoietic stem cell transplantation in patients with hematologic malignancies who lack an HLA-matched sibling or well-matched unrelated donor; however, it has a higher incidence of… read more here.
Keywords: hbo; long term; epo; therapy ... See more keywords
An Apparent Correlation Between Central Nervous System and Kidney’s Erythropoietin and TNF Alpha Expression at Peak Experimental Autoimmune Encephalomyelitis Disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1092-4
Abstract: Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelination disease associated with inflammatory reactions and attenuation of antioxidant capacity. Several lines of evidence show that organs such as the liver and kidneys can share their antioxidant… read more here.
Keywords: tnf; epo; expression; autoimmune encephalomyelitis ... See more keywords
Erythropoietin protects neurons from apoptosis via activating PI3K/AKT and inhibiting Erk1/2 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "3 Biotech"
DOI: 10.1007/s13205-019-1667-y
Abstract: The aim of this study was to explore the neuroprotective effect and the underlying mechanism of erythropoietin (EPO) on the cortical neuronal cells insulted with oxygen and glucose deprivation (OGD). Different concentrations of EPO were… read more here.
Keywords: akt; apoptosis; effect; erk1 ... See more keywords
Effect of erythropoietin production induced by hypoxia on autophagy in HepG2 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.167
Abstract: The induction of hypoxia inducible factor (HIF) and autophagy are important cellular responses to hypoxia. The production of erythropoietin (EPO) regulated by HIF is increased by hypoxia and participates in cell protection in various organs… read more here.
Keywords: production; epo; hypoxia; autophagy induction ... See more keywords
Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation
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DOI: 10.1016/j.cell.2017.02.026
Abstract: Cytokines are classically thought to stimulate downstream signaling pathways through monotonic activation of receptors. We describe a severe anemia resulting from a homozygous mutation (R150Q) in the cytokine erythropoietin (EPO). Surprisingly, the EPO R150Q mutant… read more here.
Keywords: cytokine; functional selectivity; epo; selectivity cytokine ... See more keywords
Erythropoietin regulates metabolic response in mice via receptor expression in adipose tissue, brain and bone.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental hematology"
DOI: 10.1016/j.exphem.2020.09.190
Abstract: Erythropoietin (EPO) acts by binding to erythroid progenitor cells to regulate red blood cell production. While EPO receptor (Epor) expression is highest on erythroid tissue, animal models demonstrate EPO activity in non-hematopoietic tissues is mediated,… read more here.
Keywords: tissue; bone; epo; adipose tissue ... See more keywords