Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2018.03.011
Abstract: Lipotoxicity plays an important role in the progression of chronic kidney damage via various mechanisms, such as endoplasmic reticulum stress. Several studies proposed renal lipotoxicity in glomerular and tubular cells but the effect of lipid… read more here.
Keywords: production; endoplasmic reticulum; palmitate; atf4 activation ... See more keywords
Effects of Roxadustat on Erythropoietin Production in the Rat Body
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27031119
Abstract: Anemia is a major complication of chronic renal failure. To treat this anemia, prolylhydroxylase domain enzyme (PHD) inhibitors as well as erythropoiesis-stimulating agents (ESAs) have been used. Although PHD inhibitors rapidly stimulate erythropoietin (Epo) production,… read more here.
Keywords: epo; phd inhibitors; production; epo production ... See more keywords