Epothilone D Modulates Autism-like Behaviors in the BTBR Mouse Model of Autism Spectrum Disorder
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DOI: 10.1016/j.neuroscience.2022.02.025
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder, characterized by impaired social communication, abnormal repetitive behaviors and restricted interests and/or sensory behaviors. It has been widely accepted that ASD involves a complex interplay of both… read more here.
Keywords: epothilone; autism spectrum; autism; behaviors btbr ... See more keywords
Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate
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DOI: 10.3390/ijms20051113
Abstract: A new simplified, epoxide-free epothilone analog was prepared incorporating an N-(2-hydroxyethyl)-benzimidazole side chain, which binds to microtubules with high affinity and inhibits cancer cell growth in vitro with nM potency. Building on this scaffold, a… read more here.
Keywords: epothilone; conjugate; affinity; microtubule binding ... See more keywords