Rational Design of an Epoxide Hydrolase From Spatholobus Suberectus: Enhancing Catalytic Activity and Thermostability for Efficient (R)‐Styrene Oxide Production
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DOI: 10.1002/biot.70061
Abstract: (R)‐Styrene oxide is a high‐value chiral intermediate in pharmaceutical and chemical industries, yet its enantioselective synthesis remains challenging. Here, we engineered an epoxide hydrolase from Spatholobus suberectus (SsEH) to address its limitations in catalytic activity… read more here.
Keywords: thermostability; epoxide hydrolase; catalytic activity; styrene oxide ... See more keywords
Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors
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DOI: 10.1002/cmdc.202200137
Abstract: Soluble epoxide hydrolase (sEH) is implicated as a potential therapeutic target for inflammation‐related pathologies in the context of cardiovascular, central nervous system and metabolic diseases. In our search for novel sEH inhibitors, we designed and… read more here.
Keywords: seh; seh inhibitors; soluble epoxide; epoxide hydrolase ... See more keywords
Repositioning of Small Molecules through the Inverse Virtual Screening in silico Tool: Case of Benzothiazole-Based Inhibitors of Soluble Epoxide Hydrolase (sEH).
Sign Up to like & getrecommendations! Published in 2024 at "ChemPlusChem"
DOI: 10.1002/cplu.202400234
Abstract: Computational techniques accelerate drug discovery by identifying bioactive compounds for specific targets, optimizing molecules with moderate activity, or facilitating the repositioning of inactive items onto new targets. Among them, the Inverse Virtual Screening (IVS) approach… read more here.
Keywords: soluble epoxide; virtual screening; epoxide hydrolase; benzothiazole based ... See more keywords
Soluble epoxide hydrolase inhibitory activity of phenolic glycosides from Polygala tenuifolia and in silico approach
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DOI: 10.1007/s00044-017-2096-2
Abstract: The goal of this study was to identify soluble epoxide hydrolase (sEH) inhibitors from plants. Our efforts led to the isolation of nine phenolic glycosides 1–9 from the roots of Polygala tenuifolia Willd. The structures… read more here.
Keywords: soluble epoxide; polygala tenuifolia; epoxide hydrolase; phenolic glycosides ... See more keywords
Testing Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage: Rare Diseases, Orphan Drugs, the Conundrum
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DOI: 10.1007/s12028-021-01410-1
Abstract: The Orphan Drug Act (1988) defines a “rare disease” as a disease or condition that affects less than 200,000 people in the United States. With an incidence of 7.9 (95% confidence interval 6.9–9.0) per 100,000… read more here.
Keywords: study; medicine; epoxide hydrolase; aneurysmal subarachnoid ... See more keywords
Regulation of cardiovascular biology by microsomal epoxide hydrolase.
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DOI: 10.1007/s43188-021-00088-z
Abstract: Microsomal epoxide hydrolase/epoxide hydrolase 1 (mEH/EPHX1) works in conjunction with cytochromes P450 to metabolize a variety of compounds, including xenobiotics, pharmaceuticals and endogenous lipids. mEH has been most widely studied for its role in metabolism… read more here.
Keywords: role; biology; epoxide hydrolase; metabolism ... See more keywords
Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase.
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DOI: 10.1016/j.abb.2016.10.017
Abstract: Soluble epoxide hydrolase (sEH) is an important therapeutic target of many diseases, such as chronic obstructive pulmonary disease (COPD) and diabetic neuropathic pain. It acts by hydrolyzing and thus regulating specific bioactive long chain polyunsaturated… read more here.
Keywords: soluble epoxide; orientation; epoxide hydrolase; probing orientation ... See more keywords
Natural soluble epoxide hydrolase inhibitors from Inula britanica and their potential interactions with soluble epoxide hydrolase: Insight from inhibition kinetics and molecular dynamics.
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DOI: 10.1016/j.cbi.2021.109571
Abstract: Soluble epoxide hydrolase (sEH) is a potential drug target to treat inflammation and neurodegenerative diseases. In this study, we found that the extract of Inula britanica exhibited significantly inhibitory effects against sEH, therefore, we investigated… read more here.
Keywords: soluble epoxide; epoxide hydrolase; inula britanica; inhibition kinetics ... See more keywords
Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress.
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DOI: 10.1016/j.celrep.2019.11.006
Abstract: Major depression is a serious global health concern; however, the pathophysiology underlying this condition remains unclear. While numerous studies have focused on brain-specific mechanisms, few have evaluated the role of peripheral organs in depression. Here,… read more here.
Keywords: chronic stress; soluble epoxide; epoxide hydrolase; liver soluble ... See more keywords
Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers
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DOI: 10.1016/j.chest.2016.10.058
Abstract: BACKGROUND: Smoking and COPD are risk factors for cardiovascular disease, and the pathogenesis may involve endothelial dysfunction. We tested the hypothesis that endothelium‐derived epoxyeicosatrienoic acid (EET)‐mediated endothelial function is impaired in patients with COPD and… read more here.
Keywords: soluble epoxide; patients copd; novel soluble; epoxide hydrolase ... See more keywords
In silico investigation of cycloartane triterpene derivatives from Cimicifuga dahurica (Turcz.) Maxim. roots for the development of potent soluble epoxide hydrolase inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.02.023
Abstract: In our search for natural soluble epoxide hydrolase (sEH) inhibitors from plants, we found that an ethanolic extract of the roots of Cimicifuga dahurica (Turcz.) Maxim. significantly inhibits sEH in vitro. A phytochemical study on… read more here.
Keywords: soluble epoxide; epoxide hydrolase; cycloartane; cimicifuga dahurica ... See more keywords