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Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200137
Abstract: Soluble epoxide hydrolase (sEH) is implicated as a potential therapeutic target for inflammation‐related pathologies in the context of cardiovascular, central nervous system and metabolic diseases. In our search for novel sEH inhibitors, we designed and…
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Keywords:
seh;
seh inhibitors;
soluble epoxide;
epoxide hydrolase ... See more keywords
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Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2096-2
Abstract: The goal of this study was to identify soluble epoxide hydrolase (sEH) inhibitors from plants. Our efforts led to the isolation of nine phenolic glycosides 1–9 from the roots of Polygala tenuifolia Willd. The structures…
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Keywords:
soluble epoxide;
polygala tenuifolia;
epoxide hydrolase;
phenolic glycosides ... See more keywords
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Published in 2021 at "Neurocritical Care"
DOI: 10.1007/s12028-021-01410-1
Abstract: The Orphan Drug Act (1988) defines a “rare disease” as a disease or condition that affects less than 200,000 people in the United States. With an incidence of 7.9 (95% confidence interval 6.9–9.0) per 100,000…
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Keywords:
study;
medicine;
epoxide hydrolase;
aneurysmal subarachnoid ... See more keywords
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Published in 2021 at "Toxicological research"
DOI: 10.1007/s43188-021-00088-z
Abstract: Microsomal epoxide hydrolase/epoxide hydrolase 1 (mEH/EPHX1) works in conjunction with cytochromes P450 to metabolize a variety of compounds, including xenobiotics, pharmaceuticals and endogenous lipids. mEH has been most widely studied for its role in metabolism…
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Keywords:
role;
biology;
epoxide hydrolase;
metabolism ... See more keywords
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Published in 2017 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2016.10.017
Abstract: Soluble epoxide hydrolase (sEH) is an important therapeutic target of many diseases, such as chronic obstructive pulmonary disease (COPD) and diabetic neuropathic pain. It acts by hydrolyzing and thus regulating specific bioactive long chain polyunsaturated…
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Keywords:
soluble epoxide;
orientation;
epoxide hydrolase;
probing orientation ... See more keywords
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Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109571
Abstract: Soluble epoxide hydrolase (sEH) is a potential drug target to treat inflammation and neurodegenerative diseases. In this study, we found that the extract of Inula britanica exhibited significantly inhibitory effects against sEH, therefore, we investigated…
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Keywords:
soluble epoxide;
epoxide hydrolase;
inula britanica;
inhibition kinetics ... See more keywords
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Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.11.006
Abstract: Major depression is a serious global health concern; however, the pathophysiology underlying this condition remains unclear. While numerous studies have focused on brain-specific mechanisms, few have evaluated the role of peripheral organs in depression. Here,…
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Keywords:
chronic stress;
soluble epoxide;
epoxide hydrolase;
liver soluble ... See more keywords
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Published in 2017 at "Chest"
DOI: 10.1016/j.chest.2016.10.058
Abstract: BACKGROUND: Smoking and COPD are risk factors for cardiovascular disease, and the pathogenesis may involve endothelial dysfunction. We tested the hypothesis that endothelium‐derived epoxyeicosatrienoic acid (EET)‐mediated endothelial function is impaired in patients with COPD and…
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Keywords:
soluble epoxide;
patients copd;
novel soluble;
epoxide hydrolase ... See more keywords
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Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.02.023
Abstract: In our search for natural soluble epoxide hydrolase (sEH) inhibitors from plants, we found that an ethanolic extract of the roots of Cimicifuga dahurica (Turcz.) Maxim. significantly inhibits sEH in vitro. A phytochemical study on…
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Keywords:
soluble epoxide;
epoxide hydrolase;
cycloartane;
cimicifuga dahurica ... See more keywords
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Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.02.061
Abstract: Anthocyanin derivatives are well-known secondary constituents contained in fruits. The inhibitory activity of anthocyanin derivatives toward soluble epoxide hydrolase (sEH) was tested for potential applications in the treatment of cardiovascular diseases. Anthocyanin derivatives 1-5 showed…
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Keywords:
soluble epoxide;
anthocyanin derivatives;
epoxide hydrolase;
anthocyanin ... See more keywords
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Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.04.187
Abstract: Inhibition of soluble epoxide hydrolase (sEH) is considered to be an effective treatment for inflammation-related diseases, and small molecules origin from natural products show promising activity against sEH. Two undescribed protostanes, 3β-hydroxy-25-anhydro-alisol F (1) and…
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Keywords:
alisma orientale;
soluble epoxide;
hydrolase inhibitors;
epoxide hydrolase ... See more keywords