Studies on the Catalytic Promiscuity of Limonene Epoxide Hydrolases in the Non‐hydrolytic Ring Opening of 1,2‐Epoxides
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DOI: 10.1002/cbic.201900694
Abstract: The non‐hydrolytic ring opening of 1,2‐epoxides in the presence of limonene epoxide hydrolases (LEHs) and different nucleophiles has been investigated. Lyophilized, wild‐type LEHs were tested in selected water‐saturated organic solvents in the presence of cyclohexene… read more here.
Keywords: opening epoxides; ring opening; hydrolytic ring; non hydrolytic ... See more keywords
Misclassification of PfEH1 and PfEH2 as Epoxide Hydrolases
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DOI: 10.1128/mbio.00004-17
Abstract: In their recent article (1), Spillman and colleagues report the two Plasmodium falciparum proteins PfEH1 and PfEH2 to be two novel epoxide hydrolases with an atypical active-site architecture. We strongly believe that this conclusion is… read more here.
Keywords: hydrolase; pfeh1 pfeh2; epoxide; epoxide hydrolases ... See more keywords
Gram-Scale Synthesis of (R)-P-Chlorophenyl-1,2-Ethanediol at High Concentration by a Pair of Epoxide Hydrolases
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DOI: 10.3389/fbioe.2022.824300
Abstract: (R)-p-chlorophenyl-1,2-ethanediol (pCPED) is an important intermediate for the synthesis of (R)-eliprodil that is widely applied in the treatment of ischemic stroke. To prepare (R)-pCPED with high enantiomeric excess (ee p) and yield via the enantioconvergent… read more here.
Keywords: pair epoxide; epoxide hydrolases; concentration; high concentration ... See more keywords
Epoxide Hydrolases: Multipotential Biocatalysts
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DOI: 10.3390/ijms24087334
Abstract: Epoxide hydrolases are attractive and industrially important biocatalysts. They can catalyze the enantioselective hydrolysis of epoxides to the corresponding diols as chiral building blocks for bioactive compounds and drugs. In this review article, we discuss… read more here.
Keywords: hydrolases multipotential; stabilization; multipotential biocatalysts; enzyme ... See more keywords