Epoxyeicosatrienoic acid prevents maladaptive remodeling in pressure overload by targeting calcineurin/NFAT and Smad-7.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111716
Abstract: BACKGROUND Emerging evidence demonstrates that epoxyeicosatrienoic acids (EETs) as important active eicosanoids that regulate cardiovascular homeostasis, but the mechanisms underlying its favorable anti-hypertrophic benefits in overpressure model remain obscure. METHODS AND RESULTS Four weeks after… read more here.
Keywords: cardiac hypertrophy; smad; hypertrophy; cardiac fibroblasts ... See more keywords
Orally Active Epoxyeicosatrienoic Acid Analogs.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000523
Abstract: Biologically active epoxyeicosatrienoic acid (EET) regioisomers are synthesized from arachidonic acid by cytochrome P450 epoxygenases of endothelial, myocardial, and renal tubular cells. EETs relax vascular smooth muscle and decrease inflammatory cell adhesion and cytokine release.… read more here.
Keywords: active epoxyeicosatrienoic; eet; orally active; epoxyeicosatrienoic acid ... See more keywords
A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury
Sign Up to like & getrecommendations! Published in 2019 at "Acta Physiologica"
DOI: 10.1111/apha.13297
Abstract: Imbalances in cytochrome P450 (CYP)‐dependent eicosanoid formation may play a central role in ischemic acute kidney injury (AKI). We reported previously that inhibition of 20‐hydroxyeicosatetraenoic acid (20‐HETE) action ameliorated ischemia/reperfusion (I/R)‐induced AKI in rats. Now… read more here.
Keywords: acute kidney; ischemic acute; epoxyeicosatrienoic acid; kidney injury ... See more keywords
11,12 and 14,15 epoxyeicosatrienoic acid rescue deteriorated wound healing in ischemia
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0209158
Abstract: Introduction Epoxyeicosatrienoic acids (EETs) are able to enhance angiogenesis and regulate inflammation that is especially important in wound healing under ischemic conditions. Thus, we evaluated the effect of local EET application on ischemic wounds in… read more here.
Keywords: eet; wound healing; deteriorated wound; ischemia ... See more keywords
Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9081053
Abstract: This study evaluates the effects of chronic treatment with EET-A, an orally active epoxyeicosatrienoic acid (EETs) analog, on the course of aorto-caval fistula (ACF)-induced heart failure (HF) in Ren-2 transgenic rats (TGR), a model characterized… read more here.
Keywords: treatment; heart failure; course; epoxyeicosatrienoic acid ... See more keywords