CYP2J2-produced epoxyeicosatrienoic acids attenuate ischemia/reperfusion-induced acute kidney injury by activating the SIRT1-FoxO3a pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117327
Abstract: Cytochrome P450 (CYP) epoxygenases can metabolize arachidonic acids to epoxyeicosatrienoic acids (EETs), which play a protective role in the renal system, but their involvement in ischemia/reperfusion (I/R)-induced acute kidney injury remains unknown. Here, using a… read more here.
Keywords: sirt1 foxo3a; kidney injury; epoxyeicosatrienoic acids; cyp2j2 ... See more keywords
Epoxyeicosatrienoic acids: emerging therapeutic agents for central post-stroke pain.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.104923
Abstract: Central post-stroke pain (CPSP) is chronic neuropathic pain due to a lesion or dysfunction of the central nervous system following cerebrovascular insult. This syndrome is characterized by chronic somatosensory abnormalities including spontaneous pain, hyperalgesia and… read more here.
Keywords: post stroke; epoxyeicosatrienoic acids; stroke pain; central post ... See more keywords
Role of the cytochrome P-450/ epoxyeicosatrienoic acids pathway in the pathogenesis of renal dysfunction in cirrhosis
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DOI: 10.1093/ndt/gfx354
Abstract: Background Hepatorenal syndrome (HRS) is a life-threatening complication of advanced liver cirrhosis that is characterized by hemodynamic alterations in the kidney and other vascular beds. Cytochrome P(CYP)-450 enzymes metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs)… read more here.
Keywords: renal dysfunction; epoxyeicosatrienoic acids; cirrhosis; bdl rats ... See more keywords
Abstract P2024: Treatment of Primary Hyperaldosteronism Increases Plasma Epoxyeicosatrienoic Acids
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hyp.74.suppl_1.p2024
Abstract: Epoxyeicosatrienoic acids (EETs) are lipid signaling molecules formed from arachidonic acid by the action of CYP450s. EETs cause vasodilation, exert anti-inflammatory effects, and enhance insulin secretion and sensitivity. 14,15-DHET has been reported to be increased… read more here.
Keywords: eet; hyperaldosteronism; treatment primary; primary hyperaldosteronism ... See more keywords
Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimental heart failure.
Sign Up to like & getrecommendations! Published in 2017 at "Physiological research"
DOI: 10.33549/physiolres.933350
Abstract: Pathophysiological mechanisms underlying the development of renal dysfunction and progression of congestive heart failure (CHF) remain poorly understood. Recent studies have revealed striking differences in the role of epoxyeicosatrienoic acids (EETs), active products of cytochrome… read more here.
Keywords: acf tgr; epoxyeicosatrienoic acids; progression; heart failure ... See more keywords
The Metabolism of Epoxyeicosatrienoic Acids by Soluble Epoxide Hydrolase Is Protective against the Development of Vascular Calcification
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21124313
Abstract: This study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes endothelium-derived epoxyeicosatrienoic acids, plays a role in vascular calcification. The sEH inhibitor trans-4-(4-(3-adamantan-1-yl-ureido)-cyclohexyloxy)-benzoic acid (t-AUCB) potentiated the increase in calcium deposition of rat… read more here.
Keywords: soluble epoxide; vascular calcification; epoxyeicosatrienoic acids; epoxide hydrolase ... See more keywords
Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012433
Abstract: CYP2J2 is the main epoxygenase in the heart that is responsible for oxidizing arachidonic acid to cis-epoxyeicosatrienoic acids (EETs). Once formed, EETs can then be hydrolyzed by soluble epoxide hydrolase (sEH, encoded by EPHX2) or… read more here.
Keywords: biosynthesis degradation; involved biosynthesis; epoxyeicosatrienoic acids; tissue ... See more keywords