Synthesis of peptide based epsilon toxin vaccine by covalent anchoring to tetanus toxoid.
Sign Up to like & getrecommendations! Published in 2018 at "Anaerobe"
DOI: 10.1016/j.anaerobe.2018.06.008
Abstract: The epsilon toxin (Etx) produced by Clostridium perfringens type B and D causes severe enterotoxaemia associated with a general edema and neurological alterations, leading to subsequent death and is listed as one of the most… read more here.
Keywords: epsilon toxin; peptide based; toxin; vaccine ... See more keywords
Structural pierce into molecular mechanism underlying Clostridium perfringens Epsilon toxin function
Sign Up to like & getrecommendations! Published in 2017 at "Toxicon"
DOI: 10.1016/j.toxicon.2017.01.010
Abstract: ABSTRACT Epsilon toxin of the Clostridium perfringens garnered a lot of attention due to its potential for toxicity in humans, extreme potency for cytotoxicity in mice and lack of any approved therapeutics prescribed for human.… read more here.
Keywords: epsilon toxin; toxin; action mechanism; clostridium perfringens ... See more keywords
Clostridium perfringens epsilon toxin vaccine candidate lacking toxicity to cells expressing myelin and lymphocyte protein
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DOI: 10.1038/s41541-019-0128-2
Abstract: A variant form of Clostridium perfringens epsilon toxin (Y30A-Y196A) with mutations, which shows reduced binding to Madin–Darby canine kidney (MDCK) cells and reduced toxicity in mice, has been proposed as the next-generation enterotoxaemia vaccine. Here… read more here.
Keywords: y30a y196a; epsilon toxin; toxicity; toxin ... See more keywords
Cellular effects of epsilon toxin on the cell viability and oxidative stress of normal and lung cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Microbial pathogenesis"
DOI: 10.2139/ssrn.4029507
Abstract: INTRODUCTION Clostridium perfringens is a type of gram-positive anaerobic bacilli. C.perfringens produces many toxins, of which epsilon (ε) is one of the major ones. The mechanism of epsilon's toxicity is located in the lipid of… read more here.
Keywords: lung cancer; cell; epsilon toxin; toxin ... See more keywords
A Novel Panel of Rabbit Monoclonal Antibodies and Their Diverse Applications Including Inhibition of Clostridium perfringens Epsilon Toxin Oligomerization
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DOI: 10.3390/antib7040037
Abstract: The pore-forming epsilon toxin (ETX) produced by Clostridium perfringens is among the most lethal bacterial toxins known. Sensitive antibody-based reagents are needed to detect toxin, distinguish mechanisms of cell death, and prevent ETX toxicity. Using… read more here.
Keywords: monoclonal antibodies; epsilon toxin; clostridium perfringens; oligomerization ... See more keywords
New Mutants of Epsilon Toxin from Clostridium perfringens with an Altered Receptor-Binding Site and Cell-Type Specificity
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14040288
Abstract: Epsilon toxin (Etx) from Clostridium perfringens is the third most potent toxin after the botulinum and tetanus toxins. Etx is the main agent of enterotoxemia in ruminants and is produced by Clostridium perfringens toxinotypes B… read more here.
Keywords: new mutants; clostridium perfringens; mutants epsilon; toxin ... See more keywords