Membrane lipid homeostasis dually regulates conformational transition of phosphoethanolamine transferase EptA
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DOI: 10.1038/s41467-024-54607-1
Abstract: The phosphoethanolamine transferase EptA utilizes phosphatidylethanolamine (PE) in the bacterial cell membrane to modify the structure of lipopolysaccharide, thereby conferring antimicrobial resistance on Gram-negative pathogens. Previous studies have indicated that excessive consumption of PE can… read more here.
Keywords: epta; phosphoethanolamine transferase; membrane lipid; conformational transition ... See more keywords
Regulatory Landscape of the Pseudomonas aeruginosa Phosphoethanolamine Transferase Gene eptA in the Context of Colistin Resistance
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DOI: 10.3390/antibiotics12020200
Abstract: Pseudomonas aeruginosa has the genetic potential to acquire colistin resistance through the modification of lipopolysaccharide by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) or phosphoethanolamine (PEtN), mediated by the arn operon or the eptA gene, respectively. However,… read more here.
Keywords: pseudomonas aeruginosa; colistin; gene; epta ... See more keywords