Integration of Multi-omics Data for Expression Quantitative Trait Loci (eQTL) Analysis and eQTL Epistasis.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0026-9_11
Abstract: Expression quantitative trait loci (eQTL) mapping studies identify genetic loci that regulate gene expression. eQTL mapping studies can capture gene regulatory interactions and provide insight into the genetic mechanism of biological systems. Recently, the integration… read more here.
Keywords: loci; multi omics; omics data; eqtl ... See more keywords
Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS
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DOI: 10.1016/j.ajhg.2018.04.011
Abstract: Causal genes and variants within genome-wide association study (GWAS) loci can be identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and determining which variants underlie both GWAS and eQTL signals. Most analyses,… read more here.
Keywords: schizophrenia; eqtl; landscape conditional; gwas ... See more keywords
Simultaneous test and estimation of total genetic effect in eQTL integrative analysis through mixed models
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac038
Abstract: Integration of expression quantitative trait loci (eQTL) into genome-wide association studies (GWASs) is a promising manner to reveal functional roles of associated single-nucleotide polymorphisms (SNPs) in complex phenotypes and has become an active research field… read more here.
Keywords: eqtl; cis snps; analysis; genetic effect ... See more keywords
Comprehensive Multiple eQTL Detection and Its Application to GWAS Interpretation
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DOI: 10.1534/genetics.119.302091
Abstract: Expression QTL (eQTL) detection has emerged as an important tool for unraveling the relationship between genetic risk factors and disease or clinical phenotypes. Most studies are predicated on the assumption that only a single causal… read more here.
Keywords: eqtl detection; multiple eqtl; gene expression; eqtl ... See more keywords
Expression Quantitative Trait Loci (eQTL) mapping for callose synthases in intergeneric hybrids of Citrus challenged with the bacteria Candidatus Liberibacter asiaticus
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DOI: 10.1590/1678-4685-gmb-2019-0133
Abstract: Abstract Citrus plants have been extremely affected by Huanglongbing (HLB) worldwide, causing economic losses. HLB disease causes disorders in citrus plants, leading to callose deposition in the phloem vessel sieve plates. Callose is synthesized by… read more here.
Keywords: loci; callose synthases; hybrids citrus; eqtl ... See more keywords
1722-P: Colocalization of TOPMed Whole Genome Sequencing Analysis and Tissue-Specific eQTL Signals Detects Target Genes for Type 2 Diabetes Risk
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DOI: 10.2337/db19-1722-p
Abstract: Type 2 diabetes (T2D) risk is highly heritable, and although many associated loci have been identified, analyses of regulatory regions in most whole-genome sequencing (WGS) studies have not been specific to relevant tissues. The availability… read more here.
Keywords: whole genome; tissue specific; genome sequencing; type diabetes ... See more keywords