Effective SNP ranking improves the performance of eQTL mapping.
Sign Up to like & getrecommendations! Published in 2020 at "Genetic epidemiology"
DOI: 10.1002/gepi.22293
Abstract: Genome-wide expression quantitative trait loci (eQTLs) mapping explores the relationship between gene expression and DNA variants, such as single-nucleotide polymorphism (SNPs), to understand genetic basis of human diseases. Due to the large number of genes… read more here.
Keywords: eqtl mapping; snp ranking; effective snp; improves performance ... See more keywords
QTL and eQTL mapping associated with host response to Candidatus Liberibacter asiaticus in citrandarins
Sign Up to like & getrecommendations! Published in 2020 at "Tropical Plant Pathology"
DOI: 10.1007/s40858-020-00372-7
Abstract: Huanglongbing (HLB) is a severe disease of citrus caused by the bacterium Candidatus Liberibacter. In America, the most common species is Candidatus Liberibacter asiaticus (CLas). In a previous study of the Citrus-HLB pathosystem, our group… read more here.
Keywords: associated host; eqtl mapping; qtl eqtl; host response ... See more keywords
Quantile regression for challenging cases of eQTL mapping
Sign Up to like & getrecommendations! Published in 2020 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbz097
Abstract: Mapping of expression quantitative trait loci (eQTLs) facilitates interpretation of the regulatory path from genetic variants to their associated disease or traits. High-throughput sequencing of RNA (RNA-seq) has expedited the exploration of these regulatory variants.… read more here.
Keywords: quantile regression; regression; eqtl mapping; regression challenging ... See more keywords
Expression estimation and eQTL mapping for HLA genes with a personalized pipeline
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DOI: 10.1371/journal.pgen.1008091
Abstract: The HLA (Human Leukocyte Antigens) genes are well-documented targets of balancing selection, and variation at these loci is associated with many disease phenotypes. Variation in expression levels also influences disease susceptibility and resistance, but little… read more here.
Keywords: eqtl mapping; hla genes; hla; expression ... See more keywords
eQTL mapping using allele-specific count data is computationally feasible, powerful, and provides individual-specific estimates of genetic effects
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010076
Abstract: Using information from allele-specific gene expression (ASE) can improve the power to map gene expression quantitative trait loci (eQTLs). However, such practice has been limited, partly due to computational challenges and lack of clarification on… read more here.
Keywords: genetic effects; computationally feasible; eqtl mapping; ase ... See more keywords