Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.05.018
Abstract: Dorsal root ganglia (DRG) relay sensory information to the brain, giving rise to the perception of pain, disorders of which are prevalent and burdensome. Here, we mapped expression quantitative trait loci (eQTLs) in a collection… read more here.
Keywords: root ganglia; association; dorsal root; eqtls ... See more keywords
Distant eQTLs and Non-coding Sequences Play Critical Roles in Regulating Gene Expression and Quantitative Trait Variation in Maize.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular plant"
DOI: 10.1016/j.molp.2016.06.016
Abstract: A detailed understanding of genetic architecture of mRNA expression by millions of genetic variants is important for studying quantitative trait variation. In this study, we identified 1.25M SNPs with a minor allele frequency greater than 0.05 by combining… read more here.
Keywords: variation; trait variation; quantitative trait; expression ... See more keywords
Genome-wide analysis of expression quantitative trait loci (eQTLs) reveals the regulatory architecture of gene expression variation in the storage roots of sweet potato.
Sign Up to like & getrecommendations! Published in 2020 at "Horticulture research"
DOI: 10.1038/s41438-020-0314-4
Abstract: Dissecting the genetic regulation of gene expression is critical for understanding phenotypic variation and species evolution. However, our understanding of the transcriptional variability in sweet potato remains limited. Here, we analyzed two publicly available datasets… read more here.
Keywords: sweet potato; roots sweet; expression; eqtls ... See more keywords
Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1101/2022.06.01.494352
Abstract: Here, the authors discover over 15,000 eQTLs in human kidney samples by integrating single-nucleus open chromatin data, resulting in high resolution eQTLs, increased enrichment of GWAS heritability and colocalization, followed by downstream validation. Expression quantitative… read more here.
Keywords: nucleus open; single nucleus; kidney; high resolution ... See more keywords
Integrating Genome-Wide Association and eQTLs Studies Identifies the Genes and Gene Sets Associated with Diabetes
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/1758636
Abstract: Aim To identify novel candidate genes and gene sets for diabetes. Methods We performed an integrative analysis of genome-wide association studies (GWAS) and expression quantitative trait loci (eQTLs) data for diabetes. Summary data was driven… read more here.
Keywords: analysis; association; genes gene; eqtls ... See more keywords
Systems genomics study reveals expression quantitative trait loci, regulator genes and pathways associated with boar taint in pigs
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0192673
Abstract: Boar taint is an offensive odour and/or taste from a proportion of non-castrated male pigs caused by skatole and androstenone accumulation during sexual maturity. Castration is widely used to avoid boar taint but is currently… read more here.
Keywords: trait loci; quantitative trait; boar taint; eqtls ... See more keywords
Lead Modulates trans- and cis-Expression Quantitative Trait Loci (eQTLs) in Drosophila melanogaster Heads
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00395
Abstract: Lead exposure has long been one of the most important topics in global public health because it is a potent developmental neurotoxin. Here, an eQTL analysis, which is the genome-wide association analysis of genetic variants… read more here.
Keywords: trans eqtl; analysis; lead modulates; drosophila melanogaster ... See more keywords