Direct monitoring of the conformational equilibria of the activation loop in the mitogen-activated protein kinase p38α.
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DOI: 10.1039/c8cc06128a
Abstract: Conformational transitions in protein kinases are crucial for the biological function of these enzymes. Here, we characterize and assess conformational equilibria of the activation loop and the effect of small molecule inhibitors in the MAP… read more here.
Keywords: equilibria activation; kinase p38; conformational equilibria; activation loop ... See more keywords