Private equity ownership of ophthalmology practices: how does it impact clinical research?
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DOI: 10.1097/icu.0000000000000873
Abstract: Purpose of review To explore the impact of private equity ownership of ophthalmology practices on the success of their clinical research programs. Recent findings Private equity partnership in the clinical research space has been steadily… read more here.
Keywords: equity ownership; ophthalmology; clinical research; private equity ... See more keywords
Identification of a First-in-Class SETD2 Inhibitor That Shows Potent and Selective Anti-Proliferative Activity in t(4;14) Multiple Myeloma: T(4;14) Multiple Myeloma Cells Are Dependent on Both H3K36 Di and Tri-Methylation
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-110803
Abstract: t(4;14) chromosome translocations are found in 15% of newly diagnosed multiple myeloma (MM) cases and are associated with high risk. MM cells with t(4;14) over-express the histone methyltransferase (HMT), WHSC1/MMSET/NSD2, which leads to deregulation of… read more here.
Keywords: epizyme inc; equity ownership; inc employment; employment equity ... See more keywords
Comprehensive Single-Cell RNA-Sequencing Mapping of Primary Acute Myeloid Leukemias and Profiling of NPM1-Mutated Cells
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DOI: 10.1182/blood-2018-99-111390
Abstract: Introduction: Acute myeloid leukemia (AML) evolution is a multistep process in which cells evolve from hematopoietic stem and progenitor cells (HSPCs) that acquire genetic anomalies, such as chromosomal rearrangements and mutations, which define distinct subgroups.… read more here.
Keywords: single cell; equity ownership; rna sequencing; npm1 mutations ... See more keywords
Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-112726
Abstract: Background. Allogeneic bone marrow transplant (BMT) is a potentially curative approach in patients with refractory or high risk hematologic malignancies, such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Prior to transplant, patients are… read more here.
Keywords: therapeutics employment; magenta therapeutics; equity ownership; employment equity ... See more keywords
Combinatorial Genetics Uncovers Novel Targets for the Treatment of Npm1/Cohesin Mutated AML
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DOI: 10.1182/blood-2018-99-113011
Abstract: Current precision medicine approaches typically target a single genetic mutation. However, adult acute myeloid leukemia (AML) is difficult to treat due to its genetic complexity. Approximately 30 somatic mutations have been found to be recurrent,… read more here.
Keywords: cohesin; genetics; equity ownership; mice ... See more keywords
Targeting Lymphomas Using Non-Engineered, Multi-Antigen Specific T Cells
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DOI: 10.1182/blood-2018-99-113140
Abstract: Immunotherapy is emerging as a potent therapy for a range of hematologic malignancies including lymphomas. Indeed adoptive transfer of T cells genetically engineered to express the CD19 chimeric antigen receptor (CAR) has now received FDA… read more here.
Keywords: cell; equity ownership; marker equity; specific cells ... See more keywords
CD200 Is a Stem Cell-Specific Immunosuppressive Target in AML
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DOI: 10.1182/blood-2018-99-114818
Abstract: Acute myeloid leukemia (AML) stem cells (LSC) are an extremely rare fraction of the overall disease (likely read more here.
Keywords: equity ownership; stem cell; cd200; aml ... See more keywords
Plasma Biomarker Association with Response in Acute GVHD Subjects Treated with the Combination of Itacitinib and Corticosteroids in a Phase 1 Clinical Trial
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DOI: 10.1182/blood-2018-99-116330
Abstract: BACKGROUND: Acute Graft versus Host Disease (aGVHD) represents a serious and sometimes life-threatening condition associated with patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Development of aGVHD is characterized by increased levels of inflammatory mediators… read more here.
Keywords: combination; response; equity ownership; treatment ... See more keywords
Cell-of-Origin Subtype Prediction of Diffuse Large B-Cell Lymphoma Using Gene Expression and Proteomic Data
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DOI: 10.1182/blood-2018-99-116949
Abstract: Introduction Diffuse large B-cell lymphoma (DLBCL) subtypes can be identified based on immunohistochemistry, somatic mutation and gene expression profiles. These cell-of-origin (COO) subtypes have distinct biological and pathogenic characteristics. In addition, studies have shown the… read more here.
Keywords: research institute; incyte research; equity ownership; employment equity ... See more keywords
Frequency of Tumor Lysis Syndrome Among Patients Diagnosed with Hematologic Malignancies
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DOI: 10.1182/blood-2018-99-117154
Abstract: INTRODUCTION: The risk of tumor lysis syndrome (TLS) varies depending upon the underlying malignancy, tumor burden, and anti-tumor activity of the treatment administered. With the recent approval of several anti-cancer treatments across hematologic malignancies, mitigation… read more here.
Keywords: treatment; tls; equity ownership; hematologic malignancies ... See more keywords
Treatment Patterns Among Adults with Newly Diagnosed Primary Immune Thrombocytopenia in the United States
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DOI: 10.1182/blood-2018-99-117252
Abstract: Introduction: Immune thrombocytopenia (ITP) is a rare platelet disorder that can lead to an increased tendency to bleed. Recommended first-line therapies include corticosteroids, intravenous immunoglobulin (IVIg) and intravenous (IV) anti-D. An estimated two-thirds of adult… read more here.
Keywords: treatment; equity ownership; consultancy; diagnosis ... See more keywords