The inexpensive additive N-methylmorpholine effectively decreases the equivalents of nucleophiles in the catalytic highly enantioselective arylation of aryl aldehydes.
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DOI: 10.1002/chir.22709
Abstract: Highly enantioselective arylation of aryl aldehydes catalyzed by (S)-H8 -BINOL-Ti(Oi-Pr)2 complex in the presence of N-methylmorpholine (NMM) as an effective and inexpensive additive is described for the first time. We found high enantioselectivity and yield… read more here.
Keywords: equivalents nucleophiles; enantioselective arylation; arylation aryl; aryl aldehydes ... See more keywords