Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates.
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DOI: 10.1016/j.celrep.2021.109840
Abstract: Nearly one-third of proteins are initially targeted to the endoplasmic reticulum (ER) membrane, where they are correctly folded and then delivered to their final cellular destinations. To prevent the accumulation of misfolded membrane proteins, ER-associated… read more here.
Keywords: erad membrane; membrane substrates; rhomboid pseudoproteases; retrotranslocation ... See more keywords