Abstract 1804: Durable eradication of tumors by single injections of a pHLIP-STING agonist
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1804
Abstract: Purpose: pHLIPs (pH-Low Insertion Peptides) target cell surface acidity resulting from the metabolism of cells in a solid tumor. The acidity causes pHLIPs to insert as transmembrane helices, and attached cargoes can be delivered into… read more here.
Keywords: eradication tumors; sting agonist; durable eradication; tumors single ... See more keywords
Eradication of tumors and development of anti-cancer immunity using STINGa targeted by pHLIP
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1023959
Abstract: Despite significant progress in the development of novel STING agonists (STINGa), applications appear to be challenged by the low efficiency and poor selectivity of these agents. A pH Low Insertion Peptide (pHLIP) extends the lifetime… read more here.
Keywords: eradication tumors; ct26 tumors; development; stinga ... See more keywords