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   Articles with "erap1" as a keyword



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ERAP1 rs30187 single nucleotide polymorphism does not confer disease susceptibility in North Indian children with enthesitis-related arthritis

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recommendations! Published in 2017 at "Clinical Rheumatology"

DOI: 10.1007/s10067-017-3560-6

Abstract: ERAP1 single nucleotide polymorphisms (SNP) are associated with ankylosing spondylitis. Data on ERAP1SNPs in juvenile idiopathic arthritis (JIA) is scarce. ERAP1 rs30187 SNP was shown to confer risk in the enthesitis-related arthritis (ERA) category of… read more here.

Keywords: erap1 rs30187; single nucleotide; erap1; rs30187 ... See more keywords
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Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis

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recommendations! Published in 2018 at "Human Molecular Genetics"

DOI: 10.1093/hmg/ddy319

Abstract: &NA; Birdshot Uveitis (Birdshot) is a rare eye condition that affects HLA‐A29‐positive individuals and could be considered a prototypic member of the recently proposed ‘MHC‐I (major histocompatibility complex class I)‐opathy’ family. Genetic studies have pinpointed… read more here.

Keywords: erap1 erap2; haplotype; erap1; birdshot uveitis ... See more keywords
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Behçet’s disease risk-variant HLA-B51/ERAP1-Hap10 alters human CD8 T cell immunity

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recommendations! Published in 2022 at "Annals of the Rheumatic Diseases"

DOI: 10.1136/ard-2022-222277

Abstract: Objectives The endoplasmic reticulum aminopeptidase (ERAP1) haplotype Hap10 encodes for a variant allotype of the endoplasmic reticulum (ER)-resident peptide-trimming aminopeptidase ERAP1 with low enzymatic activity. This haplotype recessively confers the highest risk for Behçet’s diseases… read more here.

Keywords: hla; cd8 cell; erap1 hap10; erap1 ... See more keywords

ERAP1 polymorphisms interactions and their association with Behçet’s disease susceptibly: Application of Model-Based Multifactor Dimension Reduction Algorithm (MB-MDR)

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recommendations! Published in 2020 at "PLoS ONE"

DOI: 10.1371/journal.pone.0227997

Abstract: Background Behçet’s disease (BD) is a chronic multi-systemic vasculitis with a considerable prevalence in Asian countries. There are many genes associated with a higher risk of developing BD, one of which is endoplasmic reticulum aminopeptidase-1… read more here.

Keywords: model based; mdr; based multifactor; beh disease ... See more keywords
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Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity via Inhibiting USP33-Mediated ADRB2 Deubiquitination.

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recommendations! Published in 2022 at "Diabetes"

DOI: 10.2337/db21-0857

Abstract: Chronic inflammation in liver induces insulin resistance systemically and in other tissues, including the skeletal muscle (SM); however, the underlying mechanisms remain largely unknown. By performing RNA-seq of primary hepatocytes from wild-type mice fed long… read more here.

Keywords: insulin; insulin sensitivity; usp33 mediated; erap1 ... See more keywords
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Polymorphisms of Antigen-Presenting Machinery Genes in Non-Small Cell Lung Cancer: Different Impact on Disease Risk and Clinical Parameters in Smokers and Never-Smokers

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recommendations! Published in 2021 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2021.664474

Abstract: Lung cancer is strongly associated with cigarette smoking; nevertheless some never-smokers develop cancer. Immune eradication of cancer cells is dependent on polymorphisms of HLA class I molecules and antigen-processing machinery (APM) components. We have already… read more here.

Keywords: never smokers; disease; erap1; lung cancer ... See more keywords