The association of ERAP1 and ERAP2 single nucleotide polymorphisms and their haplotypes with psoriasis vulgaris is dependent on the presence or absence of the HLA-C*06:02 allele and age at disease onset.
Sign Up to like & getrecommendations! Published in 2018 at "Human immunology"
DOI: 10.1016/j.humimm.2017.11.010
Abstract: The aim of this case-control study was to elucidate the role of some single nucleotide polymorphisms (SNPs) in the ERAP1 (rs27524, rs27044, rs30187, rs2287987 and rs26653) and ERAP2 (rs2248374) genes in predicting the risk for… read more here.
Keywords: psoriasis; erap1 erap2; hla allele; hla ... See more keywords
ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients.
Sign Up to like & getrecommendations! Published in 2019 at "Human immunology"
DOI: 10.1016/j.humimm.2019.02.004
Abstract: The objective of this case-control study was to evaluate the role of four single-nucleotide polymorphisms in the ERAP1 (rs2287987, rs30187, rs27044) and ERAP2 (rs2248374) genes and their haplotypes in predicting the risk for ankylosing spondylitis… read more here.
Keywords: erap1 erap2; ankylosing spondylitis; haplotypes associated; minor allele ... See more keywords
An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28799-8
Abstract: The Endoplasmatic Reticulum Aminopeptidases ERAP1 and ERAP2 are implicated in a variety of immune and non-immune functions. Most studies however have focused on their role in shaping the HLA class I peptidome by trimming peptides… read more here.
Keywords: erap2; erap1 erap2; intergenic region; expression ... See more keywords
Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy319
Abstract: &NA; Birdshot Uveitis (Birdshot) is a rare eye condition that affects HLA‐A29‐positive individuals and could be considered a prototypic member of the recently proposed ‘MHC‐I (major histocompatibility complex class I)‐opathy’ family. Genetic studies have pinpointed… read more here.
Keywords: erap1 erap2; haplotype; erap1; birdshot uveitis ... See more keywords
Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.566190
Abstract: Single nucleotide polymorphisms (SNPs) in the endoplasmic reticulum aminopeptidase (ERAP1 and ERAP2) genes are associated with the pathogenesis of bacterial and viral infections. To search for the variations in the ERAP1 and ERAP2 genes associated… read more here.
Keywords: erap1 erap2; erap2 genes; control; associated tuberculosis ... See more keywords
The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1002375
Abstract: The Endoplasmic Reticulum Aminopeptidase 1 and 2 (ERAP1 and ERAP2) and Insulin Regulated Aminopeptidase (IRAP) are three M1 zinc metalloproteases whose role in antigen processing is the refining of peptidome either in the Endoplasmic reticulum… read more here.
Keywords: system; angiotensin; antigen processing; irap ... See more keywords
The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1066483
Abstract: Introduction Critical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding. The… read more here.
Keywords: synergize self; aminopeptidases erap1; erap2 synergize; erap1 erap2 ... See more keywords
Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.863529
Abstract: Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses. Although the discrete… read more here.
Keywords: topology; functional heterodimers; erap2 form; form functional ... See more keywords
ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19?
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22041705
Abstract: Patients with coronavirus disease 2019 (COVID-19) have a wide variety of clinical outcomes ranging from asymptomatic to severe respiratory syndrome that can progress to life-threatening lung lesions. The identification of prognostic factors can help to… read more here.
Keywords: shield ras; erap1 erap2; erap2 enzymes; protective shield ... See more keywords