An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28799-8
Abstract: The Endoplasmatic Reticulum Aminopeptidases ERAP1 and ERAP2 are implicated in a variety of immune and non-immune functions. Most studies however have focused on their role in shaping the HLA class I peptidome by trimming peptides… read more here.
Keywords: erap2; erap1 erap2; intergenic region; expression ... See more keywords
Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection.
Sign Up to like & getrecommendations! Published in 2018 at "Genome research"
DOI: 10.1101/gr.240390.118
Abstract: While genetic variants are known to be associated with overall gene abundance in stimulated immune cells, less is known about their effects on alternative isoform usage. By analyzing RNA-seq profiles of monocyte-derived dendritic cells from… read more here.
Keywords: erap2; response; balancing selection; gene ... See more keywords
A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation
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DOI: 10.3390/ijms23094961
Abstract: The M1 zinc metalloproteases ERAP1, ERAP2, and IRAP play a role in HLA-I antigen presentation by refining the peptidome either in the ER (ERAP1 and ERAP2) or in the endosomes (IRAP). They have also been… read more here.
Keywords: irap expressed; binds irap; erap2; erap2 binds ... See more keywords