Inhibiting Erastin‐Induced Ferroptotic Cell Death by Purine‐Based Chelators
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202100654
Abstract: Ferroptosis is a cell death event caused by increased lipid peroxidation leading to iron‐dependent oxidative stress and is associated with a wide variety of diseases. In recent years, ferroptosis inhibition has emerged as a novel… read more here.
Keywords: cell death; cell; erastin induced; purine ... See more keywords
GOLPH3 inhibits erastin‐induced ferroptosis in colorectal cancer cells
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DOI: 10.1002/cbin.12190
Abstract: Ferroptosis is a novel form of programmed cell death and is considered to be a druggable target for colorectal cancer (CRC) therapy. However, the role of ferroptosis in CRC and its underlying mechanism are not… read more here.
Keywords: colorectal cancer; crc; erastin induced; ferroptosis ... See more keywords
Acetaminophen sensitizing erastin‐induced ferroptosis via modulation of Nrf2/heme oxygenase‐1 signaling pathway in non‐small‐cell lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29221
Abstract: Growing evidence confirms that ferroptosis plays an important role in tumor growth inhibition. However, some non‐small‐cell lung cancer (NSCLC) cell lines are less sensitive to erastin‐induced ferroptotic cell death. Elucidating the mechanism of resistance of… read more here.
Keywords: erastin; ferroptosis; lung cancer; cancer ... See more keywords
Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-022-00975-w
Abstract: Endometriosis is a chronic disorder characterized by the implantation of endometrial glands and stroma outside the uterus. However, the pathogenesis of endometriosis is still unclear. To date, there is no fully effective treatment without trauma… read more here.
Keywords: muc1; mir 145; malat1; ferroptosis ... See more keywords
Resveratrol Protects BEAS-2B Cells against Erastin-Induced Ferroptosis through the Nrf2/Keap1 Pathway
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DOI: 10.1055/a-1923-4399
Abstract: Abstract Ferroptosis is a newly discovered type of cell death that is different from other types of cell death morphologically and biologically. It is considered to play an important role in many pulmonary diseases. Currently,… read more here.
Keywords: resveratrol; induced ferroptosis; beas cells; cells erastin ... See more keywords
Theaflavin-3,3′-Digallate Inhibits Erastin-Induced Chondrocytes Ferroptosis via the Nrf2/GPX4 Signaling Pathway in Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3531995
Abstract: There is evidence that osteoarthritis (OA) is associated with ferroptosis which is a kind of lipid peroxidation-related cell death. Theaflavin-3,3′-digallate(TF3), a polyphenol compound extracted from black tea, possesses antioxidative and anti-inflammatory properties, but its effects… read more here.
Keywords: nrf2 gpx4; signaling pathway; gpx4 signaling; gpx4 ... See more keywords
Vitamin C Sensitizes Pancreatic Cancer Cells to Erastin-Induced Ferroptosis by Activating the AMPK/Nrf2/HMOX1 Pathway
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DOI: 10.1155/2022/5361241
Abstract: Ferroptosis is a type of regulated cell death that displays a promising therapeutic pathway for drug-resistant tumor cells. However, some pancreatic cancer (PC) cells are less sensitive to erastin-induced ferroptosis, and normal pancreatic cells are… read more here.
Keywords: pancreatic cancer; vitamin; erastin induced; induced ferroptosis ... See more keywords
Synergistic Effect of Erastin Combined with Nutlin-3 on Vestibular Schwannoma Cells as p53 Modulates Erastin-Induced Ferroptosis Response
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/7507857
Abstract: Vestibular schwannoma (VS) is a rare neurotology neoplasm that results in partial neurological defects. As we know, a comprehensive understanding of basic mechanisms and targeted therapy is vital for disease management. In VS, p53 has… read more here.
Keywords: vestibular schwannoma; p53; schwannoma cells; ferroptosis ... See more keywords
Knockdown of ferroportin accelerates erastin-induced ferroptosis in neuroblastoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201806_15267
Abstract: OBJECTIVE Ferroptosis is a new-found iron-dependent form of non-apoptotic regulated cell death (RCD), which is activated on therapy with several antitumor agents, but the potential mechanism remains unclear. Erastin, exhibiting selectivity for RAS-mutated cancer cells,… read more here.
Keywords: ferroptosis neuroblastoma; fpn; ferroptosis; iron ... See more keywords
Erastin-induced multi-pathway cell death in endometriosis: a mechanistic and translational narrative review
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2025.1594702
Abstract: This narrative review examines the therapeutic potential of Erastin and its derivatives for endometriosis (EMS) by integrating mechanistic, preclinical, and translational perspectives. We conducted a focused review of literature from PubMed and Web of Science… read more here.
Keywords: erastin; review; erastin induced; narrative review ... See more keywords
Short-chain fatty acids regulate erastin-induced cardiomyocyte ferroptosis and ferroptosis-related genes
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1409321
Abstract: Background Ferroptosis has been proven to contribute to the progression of myocardial ischemia/reperfusion (I/R) injury and can be inhibited or promoted by ATF3. Short-chain fatty acids (SCFAs) have shown benefits in various cardiovascular diseases with… read more here.
Keywords: ferroptosis; short chain; cardiomyocyte ferroptosis; erastin induced ... See more keywords