In Vitro Activity of Eravacycline and Comparator Antimicrobials Against 143 Strains of Bacteroides Species.
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DOI: 10.1093/ofid/ofx163.905
Abstract: Abstract Background Eravacycline (ERV is the first fully synthetic fluorocycline with activity against tetracycline (TET)-resistant organisms. In addition, it is 2–8 times more potent than tigecycline (TGC). Like other tetracyclines, it inhibits protein synthesis by… read more here.
Keywords: vitro activity; tgc; erv; eravacycline ... See more keywords
Pharmacokinetics and Comprehensive Analysis of the Tissue Distribution of Eravacycline in Rabbits
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DOI: 10.1128/aac.00275-18
Abstract: Eravacycline (7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline or TP-434) is a novel, fully synthetic broad-spectrum fluorocycline with potent activity against Gram-positive bacteria, anaerobes, and multidrug-resistant Enterobacteriaceae. We characterized the plasma pharmacokinetics of eravacycline and conducted a comprehensive analysis of the… read more here.
Keywords: tissue distribution; analysis; comprehensive analysis; concentrations highest ... See more keywords
Multicenter Clinical Evaluation of ETEST Eravacycline for Susceptibility Testing of Enterobacteriaceae and Enterococci
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DOI: 10.1128/jcm.01650-22
Abstract: Eravacycline (ERV) (brand name Xerava [Tetraphase]) is a new tetracycline-class antibacterial that has been approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for treatment of complicated intra-abdominal infections… read more here.
Keywords: multicenter clinical; evaluation; etest erv; susceptibility testing ... See more keywords
Omadacycline, Eravacycline, and Tigecycline Express Anti-Mycobacterium abscessus Activity In Vitro
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DOI: 10.1128/spectrum.00718-23
Abstract: The antimicrobial activities of four third-generation tetracycline-class drugs, omadacycline (OMC), eravacycline (ERC), tigecycline (TGC), and sarecycline (SAC), were determined for 193 M. abscessus isolates. The activities of the four drugs at two different temperatures (30°C… read more here.
Keywords: tgc; tigecycline; abscessus activity; abscessus ... See more keywords
Development of Resistance to Eravacycline by Klebsiella pneumoniae and Collateral Sensitivity-Guided Design of Combination Therapies
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DOI: 10.1128/spectrum.01390-22
Abstract: The increasing bacterial antibiotic resistance is a serious threat to global public health, which demands novel antimicrobial medicines and treatment strategies. Eravacycline is a newly approved antibiotic that belongs to the tetracycline antibiotics. ABSTRACT The… read more here.
Keywords: aztreonam avibactam; development; combination; resistance eravacycline ... See more keywords
Eravacycline in allogeneic stem cell transplant recipients: A real-world study of drug-drug interactions with cyclosporine/tacrolimus and anti-infective efficacy
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DOI: 10.1182/blood-2025-7734
Abstract: Objective: Calcineurin inhibitors (CNIs) are standard prophylaxis for acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Given their narrow therapeutic window and variable bioavailability, rigorous therapeutic drug monitoring is mandatory, particularly during… read more here.
Keywords: drug drug; administration; drug; efficacy ... See more keywords
Integrative analysis of outer membrane vesicles proteomics and whole-cell transcriptome analysis of eravacycline induced Acinetobacter baumannii strains
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DOI: 10.1186/s12866-020-1722-1
Abstract: Background Acinetobacter baumannii is a multidrug-resistant (MDR) hazardous bacterium with very high antimicrobial resistance profiles. Outer membrane vesicles (OMVs) help directly and/or indirectly towards antibiotic resistance in these organisms. The present study aims to look… read more here.
Keywords: whole cell; analysis; outer membrane; resistance ... See more keywords