ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23586
Abstract: We recently discovered a novel role for neuregulinâ1 (Nrg1) signaling in mediating spontaneous regenerative processes and functional repair after spinal cord injury (SCI). We revealed that Nrg1 is the molecular signal responsible for spontaneous functional… read more here.
Keywords: remyelination; transformation; erbb; receptor ... See more keywords
Direct Observation of Endocytosis Dynamics of Anti-ErbB Modified Single Nanocargoes.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c00184
Abstract: The ErbB receptor family, including the epidermal growth factor receptor (EGFR) and ErbB2/3/4, regulate cell proliferation, differentiation, apoptosis, motility, etc., and their abnormalities can cause cancer and other diseases. Ligand-induced endocytosis of ErbB receptors is… read more here.
Keywords: erbb receptors; erbb; anti erbb; erbb modified ... See more keywords
Canonical ErbB-2 isoform and ErbB-2 variant c located in the nucleus drive triple negative breast cancer growth
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-01430-9
Abstract: Triple negative breast cancer (TNBC) refers to tumors that do not express clinically significant levels of estrogen and progesterone receptors, and lack membrane overexpression or gene amplification of ErbB-2/HER2, a receptor tyrosine kinase. Transcriptome and… read more here.
Keywords: medicine; negative breast; isoform; erbb ... See more keywords
Lung squamous cell carcinoma and lung adenocarcinoma differential gene expression regulation through pathways of Notch, Hedgehog, Wnt, and ErbB signalling
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-77284-8
Abstract: Lung malignancies comprise lethal and aggressive tumours that remain the leading cancer-related death cause worldwide. Regarding histological classification, lung squamous cell carcinoma (LUSC) and adenocarcinoma (LUAD) account for the majority of cases. Surgical resection and… read more here.
Keywords: squamous cell; hedgehog wnt; erbb; lung squamous ... See more keywords
Temporal Dynam ics of the Neuregulin-ErbB Network in the Murine Prefrontal Cortex across the Lifespan.
Sign Up to like & getrecommendations! Published in 2020 at "Cerebral cortex"
DOI: 10.1093/cercor/bhz312
Abstract: Neuregulin-ErbB signaling is essential for numerous functions in the developing, adult, and aging brain, particularly in the prefrontal cortex (PFC). Mouse models with disrupted Nrg and/or ErbB genes are relevant to psychiatric, developmental, and age-related… read more here.
Keywords: across lifespan; erbb network; erbb; expression ... See more keywords
ERBB2 Pathway in Biliary Tract Carcinoma: Clinical Implications of a Targetable Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Oncology Research and Treatment"
DOI: 10.1159/000511919
Abstract: Background/Aims: Current chemotherapy regimens for cholangiocarcinoma (CCA) yield poor outcomes, with a median overall survival of read more here.
Keywords: biliary tract; erbb2 pathway; cca; erbb ... See more keywords
mGluR1-Dependent Long Term Depression in Rodent Midbrain Dopamine Neurons Is Regulated by Neuregulin 1/ErbB Signaling
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00346
Abstract: Increasing evidence demonstrates that the neurotrophic factor Neuregulin 1 (NRG1) and its receptors, ErbB tyrosine kinases, modulate midbrain dopamine (DA) transmission. We have previously reported that NRG1/ErbB signaling is essential for proper metabotropic glutamate receptors… read more here.
Keywords: long term; erbb; midbrain; mglur1 dependent ... See more keywords