The ErbB family and androgen receptor signaling are targets of Celecoxib in prostate cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.04.025
Abstract: Inflammation plays a central role in prostate cancer (PCa) development through significant crosstalk between the COX-2-ErbB family receptor network and androgen receptor (AR)-EGFR signaling pathways. The purpose of this work was to determine the ability… read more here.
Keywords: cancer; androgen receptor; erbb family; prostate cancer ... See more keywords
ErbB Family Signalling: A Paradigm for Oncogene Addiction and Personalized Oncology
Sign Up to like & getrecommendations! Published in 2017 at "Cancers"
DOI: 10.3390/cancers9040033
Abstract: ErbB family members represent important biomarkers and drug targets for modern precision therapy. They have gained considerable importance as paradigms for oncoprotein addiction and personalized medicine. This review summarizes the current understanding of ErbB proteins… read more here.
Keywords: addiction; erbb family; addiction personalized; oncoprotein addiction ... See more keywords
Proteasome Inhibitors Suppress ErbB Family Expression through HSP90-Mediated Lysosomal Degradation
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20194812
Abstract: Although dual EGFR/HER2 tyrosine kinase inhibitor lapatinib has provided effective clinical benefits for HER2-positive breast cancer patients, acquired resistance to this drug remains a major concern. Thus, the development of alternative therapeutic strategies is urgently… read more here.
Keywords: erbb family; proteasome inhibitors; family expression; breast cancer ... See more keywords