Examination of Low ERBB2 Protein Expression in Breast Cancer Tissue.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2021.7239
Abstract: Importance Trastuzumab deruxtecan (T-DXd) has shown efficacy in patients with breast cancer with ERBB2 immunohistochemistry (IHC) scores of 1+ or 2+ but not 0 as read in central pathology laboratories. The drug is currently being… read more here.
Keywords: ihc; erbb2; breast cancer; low erbb2 ... See more keywords
ERBB2b mRNA isoform encodes a nuclear variant of the ERBB2 oncogene in breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29762
Abstract: The presence of nuclear ERBB2 receptor‐type tyrosine kinase is one of the causes of the resistance to membrane ERBB2‐targeted therapy in breast cancers. It has been previously reported that this nuclear location arises through at… read more here.
Keywords: variant erbb2; breast; breast cancer; nuclear erbb2 ... See more keywords
ErbB1-dependent signalling and vesicular trafficking in primary afferent nociceptors associated with hypersensitivity in neuropathic pain
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2020.104961
Abstract: Effective analgesic treatment for neuropathic pain remains an unmet need, so previous evidence that epidermal growth factor receptor inhibitors (EGFRIs) provide unexpected rapid pain relief in a clinical setting points to a novel therapeutic opportunity.… read more here.
Keywords: vesicular trafficking; evidence; erbb1; neuropathic pain ... See more keywords
HER2 in Colorectal Carcinoma: Are We There yet?
Sign Up to like & getrecommendations! Published in 2020 at "Surgical pathology clinics"
DOI: 10.1016/j.path.2020.05.007
Abstract: HER2 (ERBB2) is a member of the ERBB family of receptor tyrosine kinases and functions to drive signaling in the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways. Overall, approximately 2-3% of CRCs exhibit ERBB2 amplification. Multiple phase II… read more here.
Keywords: her2 colorectal; targeted therapy; colorectal carcinoma; carcinoma yet ... See more keywords
PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.213
Abstract: The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repressed in cancers and signifies poor prognosis of breast cancer patients. In this study, deletion of Ptpro in MMTV-Erbb2 transgenic mice dramatically shortened the mammary tumor… read more here.
Keywords: driven breast; erbb2; erbb2 driven; breast cancer ... See more keywords
Imbalance of NRG1-ERBB2/3 signalling underlies altered myelination in Charcot–Marie–Tooth disease 4H
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac402
Abstract: Abstract Charcot–Marie–Tooth (CMT) disease is one of the most common inherited neurological disorders, affecting either axons from the motor and/or sensory neurons or Schwann cells of the peripheral nervous system (PNS) and caused by more… read more here.
Keywords: type iii; nrg1 type; myelination; disease ... See more keywords
Abstract 212: Identification by mass spectrometry of unique phosphoproteins subsequent to signaling through c-ErbB2
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-212
Abstract: The receptor tyrosine kinase c-ErbB2 is amplified in breast and ovarian cancer. The linear pathways through which signals by c-ErbB2 are transduced is well known. However, second generation questions that address spatial aspects of signaling… read more here.
Keywords: mass spectrometry; mass; cancer; erbb2 ... See more keywords
Abstract 4333: High incidence of ERBB2 amplification associated with microsatellite stable status in Chinese colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4333
Abstract: Introduction: Amplification of receptor tyrosine-protein kinase erbB-2 gene (ERBB2), also known as HER2, can serve as an effective biomarker for either dual targeted therapy with trastuzumab plus lapatinib or pertuzumab plus trastuzumab in treating refractory… read more here.
Keywords: status; cancer patients; colorectal cancer; chinese colorectal ... See more keywords
Abstract 249: ERBB2 and beta-1-Adrenergic Receptor Cross-talk Underlies Cardiac Dysfunction
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.249
Abstract: ERBB2 is a member of the EGFR growth factor receptor family and a primary target for anti-cancer treatment in patients diagnosed with breast cancer. ERBB2 targeting is known to cause cardiotoxicity, resulting in cardiac dilation… read more here.
Keywords: cross talk; erbb2 expression; expression; cardiac dysfunction ... See more keywords
Increased expression of neuregulin 1 in the urothelium of rat bladder with partial bladder outlet obstruction
Sign Up to like & getrecommendations! Published in 2017 at "BMC Urology"
DOI: 10.1186/s12894-017-0307-2
Abstract: BackgroundThis study determined whether changes in the expression of neuregulin (NRG) 1, erbB2 tyrosine kinase (ErbB2) and the M2 muscarinic receptor in the urothelium and detrusor muscle of the rat bladder were associated with partial… read more here.
Keywords: pboo; bladder; expression; erbb2 ... See more keywords
Real-world large-scale study of ERBB2 gene fusions and its response to afatinib in Chinese non-small cell lung cancer (NSCLC): A multicenter study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e13002
Abstract: e13002 Background: ERBB2 mutation has been found to be an oncogenic driver gene in non-small cell lung cancers (NSCLC) and ERBB2-directed therapies have shown promising results in this unique population, while little is known about… read more here.
Keywords: erbb2 fusion; study; erbb2; nsclc ... See more keywords