Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2+ breast cancer samples
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4594-0
Abstract: BackgroundHER2 positive (HER2+) breast cancers involve chromosomal structural alterations that act as oncogenic driver events.MethodsWe interrogated the genomic structure of 18 clinically-defined HER2+ breast tumors through integrated analysis of whole genome and transcriptome sequencing, coupled… read more here.
Keywords: her2 breast; erbb2 amplifications; breast; breast cancer ... See more keywords
Efficacy of histology-agnostic and molecularly-driven HER2 inhibitors for refractory cancers
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DOI: 10.18632/oncotarget.24188
Abstract: A targeted therapy is recommended in case of ERBB2 alteration for breast and gastric carcinomas, but miscellaneous other tumor types are ERBB2-altered at low prevalence. Broadening the administration of HER2 inhibitors across tumor types and… read more here.
Keywords: tumor types; erbb2 amplifications; histology; her2 inhibitors ... See more keywords
Molecular Landscape of ERBB2 Alterations in 14,956 Solid Tumors
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DOI: 10.3389/pore.2022.1610360
Abstract: ERBB2 abnormalities frequently occur and serve as rationale therapeutic targets in cancer. In this study, clinical and next-generation sequencing data from 14,956 patients across more than 20 tumor types were collected. A total of 406… read more here.
Keywords: erbb2 alterations; landscape erbb2; solid tumors; erbb2 amplifications ... See more keywords