Efficacy of Margetuximab vs Trastuzumab in Patients With Pretreated ERBB2-Positive Advanced Breast Cancer
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DOI: 10.1001/jamaoncol.2020.7932
Abstract: This phase 3 randomized clinical trial compares the clinical efficacy of margetuximab vs trastuzumab, each with chemotherapy, in patients with pretreated ERBB2-positive advanced breast cancer. read more here.
Keywords: pretreated erbb2; erbb2 positive; efficacy margetuximab; margetuximab trastuzumab ... See more keywords
Three-Year Follow-up of Neoadjuvant Chemotherapy With or Without Anthracyclines in the Presence of Dual ERBB2 Blockade in Patients With ERBB2-Positive Breast Cancer: A Secondary Analysis of the TRAIN-2 Randomized, Phase 3 Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2021.1371
Abstract: Importance Primary analysis of the TRAIN-2 study showed high pathologic complete response rates after neoadjuvant chemotherapy with or without anthracyclines plus dual ERBB2 (formerly HER2) blockade. Objective To evaluate 3-year event-free survival (EFS) and overall… read more here.
Keywords: erbb2 positive; analysis; positive breast; year ... See more keywords
Aiming at a Tailored Cure for ERBB2-Positive Metastatic Breast Cancer: A Review.
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DOI: 10.1001/jamaoncol.2021.6597
Abstract: Importance Metastatic breast cancer (MBC) has traditionally been considered incurable. Accordingly, current treatment algorithms are aimed at maintaining quality of life and improving overall survival, rather than at complete eradication of the disease. Attempts to… read more here.
Keywords: erbb2 positive; breast cancer; treatment; cure ... See more keywords
Diagnosis and Treatment of ERBB2-Positive Metastatic Colorectal Cancer: A Review.
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DOI: 10.1001/jamaoncol.2021.8196
Abstract: Importance Amplification of ERBB2 (formerly referred to as HER2) is present in nearly 3% of patients with metastatic colorectal cancer overall and 5% of patients with KRAS and NRAS wild-type tumors. Despite the availability of… read more here.
Keywords: erbb2 positive; metastatic colorectal; positive metastatic; colorectal cancer ... See more keywords
Efficacy of Ipilimumab vs FOLFOX in Combination With Nivolumab and Trastuzumab in Patients With Previously Untreated ERBB2-Positive Esophagogastric Adenocarcinoma: The AIO INTEGA Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.2228
Abstract: Importance In metastatic esophagogastric adenocarcinoma (EGA), the addition of programmed cell death 1 (PD-1) inhibitors to chemotherapy has improved outcomes in selected patient populations. Objective To investigate the efficacy of trastuzumab and PD-1 inhibitors with… read more here.
Keywords: oncology; arm; erbb2 positive; trial ... See more keywords
miR-1296-5p decreases ERBB2 expression to inhibit the cell proliferation in ERBB2-positive breast cancer
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DOI: 10.1186/s12935-017-0466-y
Abstract: BackgroundThe tumor suppressive role of miR-1296 is observed in triple negative breast cancer (TNBC). However, the effect of miR-1296-5p in ERBB2-positive breast cancers remains obscure.MethodsWhether ERBB2 was the target gene of the miR-1296-5p was predicted… read more here.
Keywords: cancer; erbb2 positive; mir 1296; breast cancer ... See more keywords
Economic evaluation of margetuximab vs. trastuzumab for pretreated ERBB2-positive advanced breast cancer in the US and China
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Public Health"
DOI: 10.3389/fpubh.2022.942767
Abstract: Objective To assess the economic evaluation of margetuximab plus chemotherapy over trastuzumab plus chemotherapy for women with pretreated ERBB2-positive advanced breast cancer in the United States (US) and China. Methods Based on the SOPHIA trial,… read more here.
Keywords: margetuximab; erbb2 positive; advanced breast; positive advanced ... See more keywords