Evaluation of Protein Levels of the Receptor Tyrosine Kinase ErbB3 in Serum.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7234-0_22
Abstract: The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases (RTK) consists of four members: EGFR1/ErbB1/HER1, ErbB2/HER2, ErbB3/HER3, and HER4/ErbB4. Signaling through these receptors regulates many key cellular activities, such as cell division, migration,… read more here.
Keywords: serum; receptor tyrosine; erbb3; biology ... See more keywords
Rewiring ERBB3 and ERK signaling confers resistance to FGFR1 inhibition in gastrointestinal cancer harbored an ERBB3-E928G mutation
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DOI: 10.1007/s13238-020-00749-z
Abstract: Recently, a large number of studies found that activation of ERBB3 (Erb-B2 receptor tyrosine kinase 3, also known as HER3) may be one of the major mechanisms underlying resistance to therapies that target the EGFR… read more here.
Keywords: inhibitor; erbb3; resistance; erbb3 e928g ... See more keywords
Targeting ErbB3 and Cellular NADPH/NADP+ Abundance Sensitizes Cutaneous Melanomas to Ferroptosis Inducers.
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DOI: 10.1021/acschembio.2c00113
Abstract: Melanoma is a serious health challenge. Ferroptosis is a regulated form of oxidative cell death that shows varied efficacy in melanoma. We aimed to better understand the molecular basis for this differential ferroptosis sensitivity. We… read more here.
Keywords: erbb3; ferroptosis inducers; nadph nadp; targeting erbb3 ... See more keywords
ErbB3 Control of Pmp22 Regulates Intestinal Barrier Function
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DOI: 10.1152/physiol.2023.38.s1.5734424
Abstract: Background: ErbB3 is a member of the ErbB/EGFR family of receptor tyrosine kinases and is the constitutively-expressed neuregulin (NRG) receptor in the intestinal epithelium. Pathways downstream of ErbB3 have been implicated in regulating tight junctions… read more here.
Keywords: pmp22; barrier function; erbb3; physiology ... See more keywords
Crystal structures of a llama VHH antibody BCD090-M2 targeting human ErbB3 receptor
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DOI: 10.12688/f1000research.13612.2
Abstract: Background: The ability of ErbB3 receptor to functionally complement ErbB1-2 and induce tumor resistance to their inhibitors makes it a unique target in cancer therapy by monoclonal antibodies. Here we report the expression, purification and… read more here.
Keywords: antibody; erbb3 receptor; crystal structures; erbb3 ... See more keywords
Impaired Expression of Neuregulin 1 and Nicotinic Acetylcholine Receptor β4 Subunit in Diverticular Disease
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00563
Abstract: Neuregulin 1 (NRG1) regulates the expression of the nicotinic acetylcholine receptor (nAChR) and is suggested to promote the survival and maintenance of the enteric nervous system (ENS), since deficiency of its corresponding receptor complex ErbB2/ErbB3… read more here.
Keywords: nachr subunit; nrg1; erbb3; expression ... See more keywords
NUF2 overexpression contributes to epithelial ovarian cancer progression via ERBB3-mediated PI3K-AKT and MAPK signaling axes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1057198
Abstract: Introduction NDC80 kinetochore complex component (NUF2) is upregulated and plays an important role in various human cancers. However, the function and mechanism of NUF2 in epithelial ovarian cancer (EOC) remain unclear. Methods NUF2 expression was… read more here.
Keywords: pi3k akt; progression; mapk signaling; erbb3 ... See more keywords
Targeting ErbB3 Receptor in Cancer with Inhibitory Antibodies from Llama
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9091106
Abstract: The human ErbB3 receptor confers resistance to the pharmacological inhibition of EGFR and HER2 receptor tyrosine kinases in cancer, which makes it an important therapeutic target. Several anti-ErbB3 monoclonal antibodies that are currently being developed… read more here.
Keywords: erbb3 receptor; erbb3; cancer; bcd090 bcd090 ... See more keywords