Crystal structures of a llama VHH antibody BCD090-M2 targeting human ErbB3 receptor
Sign Up to like & getrecommendations! Published in 2018 at "F1000Research"
DOI: 10.12688/f1000research.13612.2
Abstract: Background: The ability of ErbB3 receptor to functionally complement ErbB1-2 and induce tumor resistance to their inhibitors makes it a unique target in cancer therapy by monoclonal antibodies. Here we report the expression, purification and… read more here.
Keywords: antibody; erbb3 receptor; crystal structures; erbb3 ... See more keywords
Targeting ErbB3 Receptor in Cancer with Inhibitory Antibodies from Llama
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DOI: 10.3390/biomedicines9091106
Abstract: The human ErbB3 receptor confers resistance to the pharmacological inhibition of EGFR and HER2 receptor tyrosine kinases in cancer, which makes it an important therapeutic target. Several anti-ErbB3 monoclonal antibodies that are currently being developed… read more here.
Keywords: erbb3 receptor; erbb3; cancer; bcd090 bcd090 ... See more keywords