Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204824
Abstract: Neuregulin 4 (Nrg4) is an adipose tissue‐enriched secreted factor that modulates glucose and lipid metabolism. Nrg4 is closely associated with obesity and preserves diet‐induced metabolic disorders. However, the specific mechanisms via which Nrg4 regulates metabolic… read more here.
Keywords: neuregulin4 acts; hypothalamic erbb4; erbb4; obesity ... See more keywords
Stimulation of the four isoforms of receptor tyrosine kinase ErbB4, but not ErbB1, confers cardiomyocyte hypertrophy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30487
Abstract: Epidermal growth factor (EGF) receptors (ErbB1-ErbB4) promote cardiac development and growth, although the specific EGF ligands and receptor isoforms involved in growth/repair versus pathology remain undefined. We challenged ventricular cardiomyocytes with EGF-like ligands and observed… read more here.
Keywords: four isoforms; erbb4; hypertrophy; erbb1 ... See more keywords
The influence of the NRG1/ERBB4 signaling pathway on pulmonary artery endothelial cells
Sign Up to like & getrecommendations! Published in 2024 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12439
Abstract: Abstract This study aimed to examine the influence of the Neuregulin‐1 (NRG1)/ERBB4 signaling pathway on the function of human pulmonary artery endothelial cells (HPAECs) and investigate the underlying mechanisms. Enzyme‐linked immunosorbent assay indicated that ERBB4… read more here.
Keywords: erbb4; erbb4 expression; group; decrease ... See more keywords
A Novel Ultrasensitive In Situ Hybridization Approach to Detect Short Sequences and Splice Variants with Cellular Resolution
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0834-6
Abstract: Investigating the expression of RNAs that differ by short or single nucleotide sequences at a single-cell level in tissue has been limited by the sensitivity and specificity of in situ hybridization (ISH) techniques. Detection of… read more here.
Keywords: erbb4; expression; approach; cell ... See more keywords
Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.12.021
Abstract: ErbB4 is a transmembrane receptor tyrosine kinase that binds to neuregulins to activate signaling. Proteolytic cleavage of ErbB4 results in release of soluble fragments of ErbB4 into the interstitial fluid. Disruption of the neuregulin-ErbB4 pathway… read more here.
Keywords: erbb4 ectodomain; erbb4 fragments; erbb4; amyotrophic lateral ... See more keywords
ErbB4 signaling in dopaminergic axonal projections increases extracellular dopamine levels and regulates spatial/working memory behaviors
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/mp.2017.132
Abstract: Genetic variants of Neuregulin 1 (NRG1) and its neuronal tyrosine kinase receptor ErbB4 are associated with risk for schizophrenia, a neurodevelopmental disorder characterized by excitatory/inhibitory imbalance and dopamine (DA) dysfunction. To date, most ErbB4 studies… read more here.
Keywords: erbb4; signaling dopaminergic; erbb4 signaling; spatial working ... See more keywords
ErbB4 alternative splicing mediates fetal mouse alveolar type II cell differentiation in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Research"
DOI: 10.1038/s41390-022-02013-y
Abstract: Alternative splicing (AS) creates different protein isoforms, an important mechanism regulating cell-specific function. Little is known about AS in lung development, particularly in alveolar type II (ATII) cells. ErbB4 receptor isoforms Jma and Jmb have… read more here.
Keywords: differentiation; atii cells; erbb4; cell ... See more keywords
Circular RNA circ_0001162 promotes cell proliferation and invasion of glioma via the miR-936/ERBB4 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1932221
Abstract: The biological modulatory roles of many circular RNAs (circRNAs) have been validated in glioma. The current study was designed to research the functional mechanism of circ_0001162 in glioma progression. The quantitative real-time polymerase chain reaction… read more here.
Keywords: glioma; circ 0001162; erbb4; 0001162 glioma ... See more keywords
ErbB4‐mediated regulation of vasculogenic mimicry capability in breast cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Science"
DOI: 10.1111/cas.15258
Abstract: ErbB4 is a member of the ErbB receptor tyrosine kinase family. It has both pro‐ and anti‐oncogenic activities in tumors. Vasculogenic mimicry (VM), a phenomenon in which cancer cells form capillary‐like structures without endothelial cells,… read more here.
Keywords: cancer cells; breast cancer; erbb4; erbb4 mediated ... See more keywords
Frequency, impact and a preclinical study of novel ERBB gene family mutations in HER2-positive breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/1758835918778297
Abstract: Background: Somatic mutations in the ERBB genes (epidermal growth factor receptor: EGFR, ERBB2, ERBB3, ERBB4) promote oncogenesis and lapatinib resistance in metastatic HER2+ (human epidermal growth factor-like receptor 2) breast cancer in vitro. Our study… read more here.
Keywords: family mutations; erbb4; breast; breast cancer ... See more keywords
ERBB4 promotes the progression of inflammatory breast cancer through regulating PDGFRA
Sign Up to like & getrecommendations! Published in 2020 at "Translational Cancer Research"
DOI: 10.21037/tcr-19-2132
Abstract: Background The regulatory roles of human epidermal growth factor receptor [erb-b2 receptor tyrosine kinase 4 (ERBB)] family in tumors was received widespread attention. Although ERBB4 was crucial regulator in metastasis of malignant tumors, the exact… read more here.
Keywords: cancer; breast cancer; erbb4; regulating pdgfra ... See more keywords