Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis
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DOI: 10.1016/j.nbd.2018.12.021
Abstract: ErbB4 is a transmembrane receptor tyrosine kinase that binds to neuregulins to activate signaling. Proteolytic cleavage of ErbB4 results in release of soluble fragments of ErbB4 into the interstitial fluid. Disruption of the neuregulin-ErbB4 pathway… read more here.
Keywords: erbb4 ectodomain; erbb4 fragments; erbb4; amyotrophic lateral ... See more keywords