ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.02.014
Abstract: PURPOSE PARP inhibitor maintenance therapy in platinum sensitive sporadic ovarian cancers improves progression free survival. However, biomarker for synthetic lethality in platinum sensitive sporadic disease is yet to be defined. ERCC1-XPF heterodimer is a key… read more here.
Keywords: platinum sensitivity; platinum; ercc1 xpf; ovarian cancers ... See more keywords
Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00326
Abstract: The ERCC1-XPF heterodimer is a 5´-3´ structure-specific endonuclease, which plays an essential role in several DNA repair pathways in mammalian cells. ERCC1-XPF is primarily involved in the repair of chemically-induced helix-distorting and bulky DNA lesions,… read more here.
Keywords: inhibition; ercc1 xpf; dna repair; dna ... See more keywords
Modulation of ERCC1-XPF Heterodimerization Inhibition via Structural Modification of Small Molecule Inhibitor Side-Chains
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.819172
Abstract: Inhibition of DNA repair enzymes is an attractive target for increasing the efficacy of DNA damaging chemotherapies. The ERCC1-XPF heterodimer is a key endonuclease in numerous single and double strand break repair processes, and inhibition… read more here.
Keywords: inhibition; ercc1 xpf; inhibitor; side ... See more keywords
Function and Interactions of ERCC1-XPF in DNA Damage Response
Sign Up to like & getrecommendations! Published in 2018 at "Molecules"
DOI: 10.3390/molecules23123205
Abstract: Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An… read more here.
Keywords: damage response; dna damage; ercc1 xpf; repair ... See more keywords