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   Articles with "ereg" as a keyword



Epiregulin (EREG) is upregulated through an IL‐1β autocrine loop in Caco‐2 epithelial cells with reduced CFTR function

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recommendations! Published in 2018 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.26483

Abstract: CFTR is a cAMP‐regulated chloride channel, whose mutations produce cystic fibrosis. The impairment of CFTR activity increases the intracellular Cl− concentration, which in turn produces an increased interleukin‐1β (IL‐1β) secretion. The secreted IL‐1β then induces… read more here.

Keywords: ereg; epiregulin ereg; autocrine loop; reduced cftr ... See more keywords

Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma

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recommendations! Published in 2024 at "International Journal of Oral Science"

DOI: 10.1038/s41368-024-00311-1

Abstract: Dysregulated Epiregulin (EREG) can activate epidermal growth factor receptor (EGFR) and promote tumor progression in head and neck squamous cell carcinoma (HNSCC). However, the mechanisms underlying EREG dysregulation remain largely unknown. Here, we showed that… read more here.

Keywords: ereg; stt3b mediated; hnscc; pdl1 ... See more keywords

Abstract 2701: EREG reprograms M2-tumor-associated macrophage and suppresses colorectal cancer cell proliferation and migration

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.am2024-2701

Abstract: Colorectal cancer (CRC) represents a common malignancy within the digestive system, linked to significant morbidity and mortality rates. Tumors exert diverse effects on immune modulation, facilitating progression and metastasis. Amid the abundant immune cell populace… read more here.

Keywords: colorectal cancer; cancer; cancer cells; tumor associated ... See more keywords

Epiregulin (EREG) and Myocardin Related Transcription Factor A (MRTF-A) Form a Feedforward Loop to Drive Hepatic Stellate Cell Activation

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recommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2020.591246

Abstract: Trans-differentiation of quiescent hepatic stellate cells (HSC) into myofibroblast cells is considered the linchpin of liver fibrosis. A myriad of signaling pathways contribute to HSC activation and consequently liver fibrosis. Epidermal growth factor (EGF) family… read more here.

Keywords: transcription; hsc activation; activation; ereg ... See more keywords