Characterization of stage-specific tumor progression in TMPRSS2-ERG (fusion)-driven and non-fusion-driven prostate cancer in GEM models.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23413
Abstract: In the present study, we performed a comparative stage-specific pathological and molecular marker evaluation of TMPRSS2-ERG fusion and PTEN loss-driven (TMPRSS2-ERG. Ptenflox/flox ) versus non-fusion-driven prostate tumorigenesis (Hi-Myc) in mice. Anterior, ventral, and dorsolateral prostates… read more here.
Keywords: fusion driven; fusion; erg fusion; stage ... See more keywords
Prostate cancer: Stuck in the middle: interstitial genes in TMPRSS2–ERG fusion
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Urology"
DOI: 10.1038/nrurol.2017.208
Abstract: more frequently in very-low-risk and low-risk prostate cancer tumours than in tumours in higher risk categories. Furthermore, fusions containing interstitial genes are less likely to be associated with biochemical recurrence. Identifying patients with fusion-positive cancer… read more here.
Keywords: risk; tmprss2 erg; erg fusion; low risk ... See more keywords
Semi-Supervised, Attention-Based Deep Learning for Predicting TMPRSS2:ERG Fusion Status in Prostate Cancer Using Whole Slide Images
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-23-0639
Abstract: Abstract Prostate cancer harbors several genetic alterations, the most prevalent of which is TMPRSS2:ERG gene fusion, affecting nearly half of all cases. Capitalizing on the increasing availability of whole-slide images (WSI), this study introduces a… read more here.
Keywords: fusion; prostate cancer; erg fusion; tmprss2 erg ... See more keywords
The impact of PTEN deletion, TMPRSS2 : ERG fusion, and androgen receptor variant 7 (AR-V7) on resistance to novel hormone therapies (NHTs) in castrate-resistant prostate cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.e17036
Abstract: e17036 Background: Despite improved treatment outcomes of prostate cancer (PC) from NHTs, acquired resistance via AR-dependent and/or AR-independent pathways remains a challenge. Here, we examined the role of AR-V7 expression, PTEN loss, and TMPRSS2:ERG fusion… read more here.
Keywords: prostate cancer; erg fusion; tmprss2 erg;
Association of germline genetic variants with TMPRSS2-ERG fusion status in prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "Oncotarget"
DOI: 10.18632/oncotarget.27534
Abstract: Introduction: Oncogenic activation of ERG resulting from TMPRSS2-ERG gene fusion is a key molecular genetic alteration in prostate cancer (CaP). The frequency of ERG fusion is variable by race; however, there are limited data available… read more here.
Keywords: status; prostate; erg fusion; fusion status ... See more keywords
Past, Current, and Future Strategies to Target ERG Fusion-Positive Prostate Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14051118
Abstract: Simple Summary In addition to its role in development and in the vascular and hematopoietic systems, ERG plays a central role in prostate cancer. Approximately 40–50% of prostate cancer cases are characterized by ERG gene… read more here.
Keywords: erg fusion; prostate; prostate cancer;
Correlation between ERG Fusion Protein and Androgen Receptor Expression by Immunohistochemistry in Prostate, Possible Role in Diagnosis and Therapy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cancer"
DOI: 10.7150/jca.16751
Abstract: Background: Recent discovery of gene rearrangements have brought a new look to the molecular pathogenesis of cancer. Gene fusions occur in nearly 60% of prostate adenocarcinoma, being the TMPRSS2-ERG one of the most common. Evidence… read more here.
Keywords: prostate; erg fusion; expression; role ... See more keywords