Long-term Ergotamine Derivative Therapy for Migraine Associated with Pachymeningitis and Sixth Cranial Nerve Palsy
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Ophthalmology"
DOI: 10.1080/01658107.2018.1526957
Abstract: ABSTRACT Chronic use of ergotamine derivatives has been well described in the literature to cause retroperitoneal, pleural, pericardial and valvular fibrosis. While acute migraine treatment advances have resulted in a reduction of ergotamine derivatives prescribing,… read more here.
Keywords: nerve palsy; migraine; cranial nerve; long term ... See more keywords
The Application of the Neuroprotective and Potential Antioxidant Effect of Ergotamine Mediated by Targeting N-Methyl-D-Aspartate Receptors
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DOI: 10.3390/antiox11081471
Abstract: (1) Background: The N-methyl-D-aspartate receptors (NMDARs) mediate fast excitatory currents leading to depolarization. Postsynaptic NMDARs are ionotropic glutamate receptors that mediate excitatory glutamate or glycine signaling in the CNS and play a primary role in… read more here.
Keywords: effect; methyl aspartate; aspartate receptors; ergotamine ... See more keywords
Ergotamine Stimulates Human 5-HT4-Serotonin Receptors and Human H2-Histamine Receptors in the Heart
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DOI: 10.3390/ijms24054749
Abstract: Ergotamine (2′-methyl-5′α-benzyl-12′-hydroxy-3′,6′,18-trioxoergotaman) is a tryptamine-related alkaloid from the fungus Claviceps purpurea. Ergotamine is used to treat migraine. Ergotamine can bind to and activate several types of 5-HT1-serotonin receptors. Based on the structural formula of ergotamine,… read more here.
Keywords: ht4 serotonin; histamine receptors; receptors human; serotonin receptors ... See more keywords